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Details on Person PKMYT1 phosphorylates CCNA:CDK1

Class:IdReaction:170116
_displayNamePKMYT1 phosphorylates CCNA:CDK1
_doReleaseTRUE
_timestamp2025-02-26 22:28:13
catalystActivity[CatalystActivity:157883] protein serine/threonine kinase activity of PKMYT1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:170118] Matthews, L, 2005-12-23 13:38:25
edited[InstanceEdit:9929251] Orlic-Milacic, Marija, 2024-11-23
figure[Figure:72793] /figures/cyclinab_cdk1_p.jpg
input[SimpleEntity:113592] ATP [cytosol]
[CandidateSet:170091] CCNA:CDK1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:170221] Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
modified[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929250] Orlic-Milacic, Marija, 2024-11-23
[InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18
[InstanceEdit:9936325] Orlic-Milacic, Marija, 2025-01-22
[InstanceEdit:9939409] Orlic-Milacic, Marija, 2025-02-26
namePKMYT1 phosphorylates CCNA:CDK1
Myt-1 mediated phosphorylation of Cyclin A:Cdc2
output[SimpleEntity:29370] ADP [cytosol]
[CandidateSet:170085] CCNA:p-T14-CDK1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2005-04-11
reviewed[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360364] R-HSA-170116.4
summation[Summation:170217]

PKMYT1 (Myt1), which localizes preferentially to the endo...

(hasEvent)[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)[BlackBoxEvent:170088] Translocation of CCNA:p-T14-CDK1 to the nucleus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9939692] Update Tracker - [Reaction:170116] PKMYT1 phosphorylates CCNA:CDK1 - v92:[modifyText, removeLiteratureReference]
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