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Details on Person CAK phosphorylates CDK1 bound to CCNB1

Class:Id	Reaction:170076
_displayName	CAK phosphorylates CDK1 bound to CCNB1
_doRelease	TRUE
_timestamp	2025-01-22 15:36:32
catalystActivity	[CatalystActivity:69222] protein serine/threonine kinase activity of CAK [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:170080] Matthews, L, 2005-12-23 13:22:34
edited	[InstanceEdit:9929386] Orlic-Milacic, Marija, 2024-11-25
input	[Complex:170056] CCNB1:p-T14-CDK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:77499] Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. [LiteratureReference:9928866] Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells [LiteratureReference:9929418] Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
modified	[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981735] Orlic-Milacic, Marija, 2017-03-13 [InstanceEdit:9006375] Orlic-Milacic, Marija, 2017-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929415] Orlic-Milacic, Marija, 2024-11-25 [InstanceEdit:9929416] Orlic-Milacic, Marija, 2024-11-25 [InstanceEdit:9929419] Orlic-Milacic, Marija, 2024-11-25 [InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18 [InstanceEdit:9936323] Orlic-Milacic, Marija, 2025-01-22
name	CAK phosphorylates CDK1 bound to CCNB1 CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
output	[Complex:170073] CCNB1:p-T14,T161-CDK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:170055] Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360647] R-HSA-170076.5
summation	[Summation:170195] Full activity of most CDKs is dependent on CAK mediated phos...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)	[Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes [Homo sapiens] [Reaction:170126] Phosphorylation of Cyclin B1 in the CRS domain [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781094] Update Tracker - [Reaction:170076] CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes - v61:[modifyText] [_UpdateTracker:9939637] Update Tracker - [Reaction:170076] CAK phosphorylates CDK1 bound to CCNB1 - v92:[modifyText, removeLiteratureReference]
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