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Details on Person Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm

Class:Id	Reaction:170072
_displayName	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
_doRelease	TRUE
_timestamp	2022-02-08 21:59:37
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:170080] Matthews, L, 2005-12-23 13:22:34
input	[Complex:170065] CCNB1:p-T14,Y15,T161-CDK1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:170052] MPF localization is controlled by nuclear export [LiteratureReference:170214] Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
modified	[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981825] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:9006375] Orlic-Milacic, Marija, 2017-05-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9764055] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
output	[Complex:170068] CCNB1:p-T14,Y15,T161-CDK1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes [Homo sapiens] [Reaction:170076] CAK phosphorylates CDK1 bound to CCNB1 [Homo sapiens] [Reaction:75028] Phosphorylation of Wee1 kinase by Chk1 [Homo sapiens] [Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:170055] Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes [Homo sapiens]
regulatedBy	[PositiveRegulation:170059] Positive regulation by 'XPO1 [nucleoplasm]'
regulationReference	[RegulationReference:9642413] Positive regulation by 'XPO1 [nucleoplasm]' MPF localization is controlled by nuclear export
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360096] R-HSA-170072.7
summation	[Summation:170216] During interphase, cyclin B1 shuttles continuously in and ou...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764052] Futile Cycle: Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780888] Update Tracker - [Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm - v61:[modifyText]
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