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Details on Person Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes

Class:Id	Reaction:170070
_displayName	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
_doRelease	TRUE
_timestamp	2025-01-22 15:40:03
catalystActivity	[CatalystActivity:69254] protein tyrosine kinase activity of WEE1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:170080] Matthews, L, 2005-12-23 13:22:34
edited	[InstanceEdit:9929727] Orlic-Milacic, Marija, 2024-11-27
figure	[Figure:72793] /figures/cyclinab_cdk1_p.jpg
input	[Complex:170073] CCNB1:p-T14,T161-CDK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:170219] Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase [LiteratureReference:8981828] Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins [LiteratureReference:8981832] Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15 [LiteratureReference:77500] Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle [LiteratureReference:9928910] Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts
modified	[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 [InstanceEdit:210727] Matthews, L, 2008-01-15 16:04:41 [InstanceEdit:2026130] Orlic-Milacic, M, 2011-12-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981735] Orlic-Milacic, Marija, 2017-03-13 [InstanceEdit:8981736] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:8981825] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:8981831] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:8981834] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:9006375] Orlic-Milacic, Marija, 2017-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929423] Orlic-Milacic, Marija, 2024-11-25 [InstanceEdit:9929678] Orlic-Milacic, Marija, 2024-11-27 [InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18 [InstanceEdit:9936326] Orlic-Milacic, Marija, 2025-01-22
name	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
output	[Complex:170065] CCNB1:p-T14,Y15,T161-CDK1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:170076] CAK phosphorylates CDK1 bound to CCNB1 [Homo sapiens] [Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:75028] Phosphorylation of Wee1 kinase by Chk1 [Homo sapiens] [Reaction:176116] Recruitment and activation of Chk1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9929670] Negative regulation by 'p-S-CCNA:p-T161-CDK1 [nucleoplasm]'
releaseDate	2005-04-11
reviewed	[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360146] R-HSA-170070.5
structureModified	[InstanceEdit:9929678] Orlic-Milacic, Marija, 2024-11-27
summation	[Summation:170201] WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CC...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens] [Pathway:69478] G2/M DNA replication checkpoint [Homo sapiens] [Pathway:75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [Homo sapiens]
(precedingEvent)	[Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Homo sapiens] [Reaction:170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781016] Update Tracker - [Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9939647] Update Tracker - [Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes - v92:[modifyText, removeLiteratureReference, removeRegulator]
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