Query author contributions in Reactome
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Details on Person TRIF recruits TRAF6 via a specific TRAF6-binding sequence an...
| Class:Id | Summation:169989 |
|---|---|
| _displayName | TRIF recruits TRAF6 via a specific TRAF6-binding sequence an... |
| _timestamp | 2006-04-11 02:47:41 |
| created | [InstanceEdit:169938] Gillespie, ME, 2005-12-19 05:13:24 |
| literatureReference | [LiteratureReference:169969] Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death [LiteratureReference:170017] Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice [LiteratureReference:169937] TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling |
| modified | [InstanceEdit:177903] Gillespie, ME, 2006-04-11 02:47:40 |
| text | TRIF recruits TRAF6 via a specific TRAF6-binding sequence and initiates the NF-kB signaling pathway. Recruitment of TRAF6 by TRIF leads to recruitment of TAB2, TAK1 and PKR followed by release of the whole complex to the cytoplasm and activation of the IKK complex and MAP kinases. TRAF6 is recruited to the activated TLR receptor complex and is itself activated by IRAK1 that binds to its TRAF domain. The IRAK1/TRAF6 complex then dissociates from the receptor and associates with TGF-activated kinase 1 (TAK1) and TAK1 binding proteins, TAB1 and TAB2. |
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No pathways have been reviewed or authored by TRIF recruits TRAF6 via a specific TRAF6-binding sequence an... (169989)
