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Details on Person Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex

Class:IdReaction:169828
_displayNameActivated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex
_doReleaseTRUE
_timestamp2017-08-10 15:44:01
authored[InstanceEdit:169825] Jassal, B, 2005-12-08 15:49:08
catalystActivity[CatalystActivity:164804] protein serine/threonine kinase activity of Activated DAkt1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:169825] Jassal, B, 2005-12-08 15:49:08
edited[InstanceEdit:169825] Jassal, B, 2005-12-08 15:49:08
input[Complex:110484] DTSC1:DTSC2 complex [cytosol] [Drosophila melanogaster]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:169833] Akt regulates growth by directly phosphorylating Tsc2
modified[InstanceEdit:169831] Jassal, B, 2005-12-08 16:03:15
[InstanceEdit:170647] Jassal, B, 2006-01-09 10:49:39
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9015310] D'Eustachio, Peter, 2017-08-09
[InstanceEdit:9015637] D'Eustachio, Peter, 2017-08-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex
output[EntityWithAccessionedSequence:169826] Phospho-DTSC2 [cytosol] [Drosophila melanogaster]
[EntityWithAccessionedSequence:110480] TSC1 [cytosol] [Drosophila melanogaster]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2006-01-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8916743] R-DME-169828.2
summation[Summation:169823] DTSC2 is inactivated by DAkt1-dependent phosphorylation of r...
(hasEvent)[Pathway:110523] TOR signaling pathway [Drosophila melanogaster]
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