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Details on Person The interferon regulatory factors (IRF) consist of a growing...
| Class:Id | Summation:169822 |
|---|---|
| _displayName | The interferon regulatory factors (IRF) consist of a growing... |
| _timestamp | 2005-12-07 11:41:34 |
| created | [InstanceEdit:169821] de Bono, B, 2005-12-07 11:41:32 |
| literatureReference | [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical [LiteratureReference:166253] Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation |
| text | The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-/) gene promoters, as well as the interferon-stimulated response element (ISRE) of some IFN-stimulated genes. IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, which are located in the carboxy terminus of IRF-3. Phosphorylation results in the cytoplasm-to-nucleus translocation of IRF-3, DNA binding, and increased transcriptional activation. This phosphorylation induces dimerization and association with the coactivators CREB-binding protein/p300, and the resultant complex activates the target genes in the nucleus. |
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No pathways have been reviewed or authored by The interferon regulatory factors (IRF) consist of a growing... (169822)
