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Details on Person TRAF6 binding to MAPK kinase kinase 1 (MEKK1) is mediated by...

Class:IdSummation:169804
_displayNameTRAF6 binding to MAPK kinase kinase 1 (MEKK1) is mediated by...
_timestamp2012-11-16 09:49:02
created[InstanceEdit:169803] de Bono, B, 2005-12-07 10:37:43
literatureReference[LiteratureReference:166872] ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
[LiteratureReference:933487] Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
[LiteratureReference:165931] MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
[LiteratureReference:975215] Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
modified[InstanceEdit:975200] Shamovsky, V, 2010-09-22
[InstanceEdit:975212] Shamovsky, V, 2010-09-22
[InstanceEdit:975218] Shamovsky, V, 2010-09-22
[InstanceEdit:2586715] Shamovsky, V, 2012-11-16
textTRAF6 binding to MAPK kinase kinase 1 (MEKK1) is mediated by the adapter protein evolutionarily conserved signaling intermediate in Toll pathway or in short ECSIT (Kopp E et al 1999). Induced MEKK1 can activate both IKK alpha and IKK beta thus leading to induction of NF-kappa-B activation. MEKK1 was also shown to induce ERK1/2 and JNK activation [Yujiri T et al 1998].

Although TRAF6 interacts with several upstream mediators (IRAK1, IRAK2, TRIF), there is no data showing MEKK1 participating in the interaction with the TRAF6 activators. Therefore this reaction is simplified to include only TRAF6 and MEKK1.

(summation)[Reaction:166869] TRAF6 binds MEKK1 [Homo sapiens]
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