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Details on Person First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...

Class:Id	Summation:169775
_displayName	First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...
_timestamp	2012-11-16 08:17:50
created	[InstanceEdit:169774] de Bono, B, 2005-12-06 15:39:32
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
modified	[InstanceEdit:2586668] Shamovsky, V, 2012-11-16
text	First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.
(summation)	[Reaction:166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal [Homo sapiens] [Reaction:975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 [Homo sapiens] [Reaction:975878] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR [Homo sapiens]
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No pathways have been reviewed or authored by First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu... (169775)