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Details on Person Phosphorylated Shc recruits the SH2 domain of the adaptor pr...
| Class:Id | Summation:169697 |
|---|---|
| _displayName | Phosphorylated Shc recruits the SH2 domain of the adaptor pr... |
| _timestamp | 2006-12-01 09:44:19 |
| created | [InstanceEdit:169684] Jassal, Bijay, 2005-11-30 |
| modified | [InstanceEdit:187730] Jassal, Bijay, 2006-09-21 [InstanceEdit:188569] Jassal, Bijay, 2006-10-18 [InstanceEdit:188582] Jassal, Bijay, 2006-10-18 [InstanceEdit:189689] Jassal, B, 2006-12-01 09:43:36 |
| text | Phosphorylated Shc recruits the SH2 domain of the adaptor protein GRB2, which is complexed with SOS, an exchange factor for RAS and RAC, through its SH3 domain. Besides SOS, the GRB2 SH3 domain can associate with other intracellular targets, including GAB1. Erk and Rsk mediated phosphorylation results in dissociation of the SOS-Grb2 complex. This may explain why Erk activation through Shc and Grb2-SOS is transient. |
| (summation) | [Reaction:167210] Phosphorylated Shc binds with the Grb2:SOS complex [Homo sapiens] |
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No pathways have been reviewed or authored by Phosphorylated Shc recruits the SH2 domain of the adaptor pr... (169697)
