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Class:Id Reaction:169680 _displayName IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel _doRelease TRUE _timestamp 2025-06-02 14:56:39 authored [InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05 catalystActivity [CatalystActivity:9947012] ligand-gated calcium channel activity of ITPR tetramers [endoplasmic reticulum membrane] compartment [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane created [InstanceEdit:169684] Jassal, Bijay, 2005-11-30 edited [InstanceEdit:188340] Jassal, Bijay, 2006-10-10 inferredFrom
input [SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:114520] I(1,4,5)P3 [cytosol] [DefinedSet:5622009] ITPR tetramers [endoplasmic reticulum membrane] [Homo sapiens] internalReviewed [InstanceEdit:9947030] D'Eustachio, Peter, 2025-04-30 modified [InstanceEdit:182105] Jassal, Bijay, 2006-07-06 [InstanceEdit:187730] Jassal, Bijay, 2006-09-21 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188624] Jassal, Bijay, 2006-10-19 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:204298] Jassal, Bijay, 2007-11-28 [InstanceEdit:374877] Jassal, Bijay, 2008-08-05 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:416532] May, B, 2009-03-29 09:37:57 [InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422280] May, B, 2009-05-27 19:37:59 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:443066] May, B, 2009-10-02 [InstanceEdit:660810] D'Eustachio, P, 2010-05-01 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1168378] May, B, 2010-12-18 [InstanceEdit:2024060] Williams, MG, 2011-12-13 [InstanceEdit:2566471] D'Eustachio, P, 2012-11-08 [InstanceEdit:5607730] Garapati, P V, 2014-07-14 [InstanceEdit:9664264] Murillo, Julieth, 2019-10-22 [InstanceEdit:9664534] Murillo, Julieth, 2019-10-25 [InstanceEdit:9673428] Murillo, Julieth, 2020-01-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30 [InstanceEdit:9947029] D'Eustachio, Peter, 2025-04-30 [InstanceEdit:9953426] D'Eustachio, Peter, 2025-06-02 name IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel output [Complex:169696] ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] [Homo sapiens] precedingEvent [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens] [Reaction:111879] PIP2 hydrolysis [Homo sapiens] [Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Homo sapiens] [Reaction:1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane [Homo sapiens] [Reaction:1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol [Homo sapiens] [Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Homo sapiens] [Reaction:1855217] I(1,4,5)P3 transports from the ER lumen to the cytosol [Homo sapiens] [Reaction:398193] PLC beta-mediated PIP2 hydrolysis [Homo sapiens] [Reaction:114689] PLC gamma 2-mediated PIP2 hydrolysis [Homo sapiens] [Reaction:202407] PLC-gamma1 hydrolyses PIP2 [Homo sapiens] previousReviewStatus [ReviewStatus:9821385] four stars releaseDate 2008-12-17 reviewed [InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9953425] Hill, David P, 2025-06-02 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:361975] R-HSA-169680.5 structureModified [InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30 summation [Summation:169681] The IP3 receptor (IP3R) is an IP3-gated calcium channel. It ... (hasEvent) [Pathway:112043] PLC beta mediated events [Homo sapiens] [Pathway:422356] Regulation of insulin secretion [Homo sapiens] [Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens] [Pathway:1489509] DAG and IP3 signaling [Homo sapiens] [Pathway:2029485] Role of phospholipids in phagocytosis [Homo sapiens] [Pathway:2871809] FCERI mediated Ca+2 mobilization [Homo sapiens] [Pathway:4086398] Ca2+ pathway [Homo sapiens] [Pathway:5218921] VEGFR2 mediated cell proliferation [Homo sapiens] [Pathway:5607763] CLEC7A (Dectin-1) induces NFAT activation [Homo sapiens] [Pathway:9664323] FCGR3A-mediated IL10 synthesis [Homo sapiens] (precedingEvent) [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:4420052] Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT [Homo sapiens] (updatedInstance) [_UpdateTracker:9790576] Update Tracker - [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - v33:[add_removeInput] [_UpdateTracker:9791491] Update Tracker - [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - v29:[removeCatalystActivity] [_UpdateTracker:9953706] Update Tracker - [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel - v93:[add_removeInput, removeCatalystActivity]
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