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Details on Person The MCM2-7 complex is the putative replicative helicase that...

Class:IdSummation:169443
_displayNameThe MCM2-7 complex is the putative replicative helicase that...
_timestamp2011-12-22 15:21:33
created[InstanceEdit:169437] Gopinathrao, G, 2005-11-29 15:17:23
literatureReference[LiteratureReference:69040] A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex
[LiteratureReference:69045] Uninterrupted MCM2-7 function required for DNA replication fork progression
[LiteratureReference:169433] The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts
[LiteratureReference:169438] Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures
[LiteratureReference:169434] Mcm4,6,7 uses a 'pump in ring' mechanism to unwind DNA by steric exclusion and actively translocate along a duplex
[LiteratureReference:449162] Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture
modified[InstanceEdit:169495] Gopinathrao, G, 2005-11-29 20:48:39
[InstanceEdit:177273] D'Eustachio, P, 2006-03-25 20:37:49
[InstanceEdit:449161] D'Eustachio, P, 2009-11-28
[InstanceEdit:2026119] Orlic-Milacic, M, 2011-12-22
textThe MCM2-7 complex is the putative replicative helicase that unwinds replication forks. While an S.erevisiae MCM hexameric complex consisting of one copy of each of the six subunits has been reconstituted in vitro from purified subunits (Davey et al. 2003), an active helicase can be assembled with three of the six MCM proteins, MCM4, MCM6 and MCM7, in human (Ishimi,1997), S. pombe (Lee and Hurwitz, 2001) and S. cerevisiae (Kaplan et al., 2003). However, this in vitro reaction may not represent the in vivo situation. In vivo experiments suggest that all six subunits are required at the replication fork (Labib et al., 2000; reviewed by Tye and Sawyer, 2000).
(summation)[Reaction:169439] Yeast Mcm2-7 mediated fork unwinding [Saccharomyces cerevisiae]
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