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Details on Person UniProt:P03508 NS
Class:Id
ReferenceGeneProduct:169126
_chainChangeLog
chain:1-121 added on Sat February 7 2015
_displayName
UniProt:P03508 NS
_timestamp
2023-11-03 15:09:53
chain
chain:1-121
checksum
ABFAC522B4F14854
comment
FUNCTION Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.SUBUNIT Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.INTERACTION Average number present in a viral particle is estimated to be 130-200 molecules.SIMILARITY Belongs to the influenza viruses NEP family.
