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Details on Person UniProt:P03428 PB2
Class:Id
ReferenceGeneProduct:169094
_chainChangeLog
chain:1-759 added on Sat February 7 2015
_displayName
UniProt:P03428 PB2
_timestamp
2024-08-09 19:23:52
chain
chain:1-759
checksum
10D2D1608AE536D2
comment
FUNCTION Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.SUBUNIT Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus) (PubMed:28169297). Interacts with nucleoprotein NP (via N-terminus) (PubMed:22570712, PubMed:25043584). Interacts (via N-terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response (PubMed:20538852, PubMed:23246644).INTERACTION Belongs to the influenza viruses PB2 family.
3D-structure Alternative splicing Cap snatching Eukaryotic host gene expression shutoff by virus Eukaryotic host transcription shutoff by virus Host gene expression shutoff by virus Host mitochondrion Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host MAVS by virus Inhibition of host RLR pathway by virus Inhibition of host RNA polymerase II by virus mRNA capping mRNA processing Reference proteome Viral immunoevasion Viral transcription Virion
