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Details on Person UniProt:P06821 M

Class:Id	ReferenceGeneProduct:169056
_chainChangeLog	chain:1-97 added on Fri February 6 2015
_displayName	UniProt:P06821 M
_timestamp	2023-11-03 15:49:31
chain	chain:1-97
checksum	85858F6E84A97AB8
comment	FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.ACTIVITY REGULATION The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity. Emergence of amantadine-resistant variants is usually rapid.SUBUNIT Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1.INTERACTION Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).ALTERNATIVE PRODUCTS Only the first 9 residues are shared by the 2 isoforms.DOMAIN Cytoplasmic tail plays an important role in virion assembly and morphogenesis.MISCELLANEOUS When the channel is activated, one or more imidazole moieties of His-37 probably become bi-protonated.SIMILARITY Belongs to the influenza viruses matrix protein M2 family.
created	[InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
description	recommendedName: fullName evidence="1"Matrix protein 2 alternativeName: fullName evidence="1"Proton channel protein M2
geneName	M
identifier	P06821
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Disulfide bond Glycoprotein Host cell membrane Host membrane Host-virus interaction Hydrogen ion transport Inhibition of host autophagy by virus Ion channel Ion transport Lipoprotein Membrane Palmitate Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Transport Viral ion channel Virion
modified	[InstanceEdit:169470] Gillespie, ME, 2005-11-29 19:12:13 [InstanceEdit:169470] Gillespie, ME, 2005-11-29 19:12:13 [InstanceEdit:169470] Gillespie, ME, 2005-11-29 19:12:13 [InstanceEdit:169470] Gillespie, ME, 2005-11-29 19:12:13 [InstanceEdit:169481] Gillespie, ME, 2005-11-29 19:34:38 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031717] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name	M
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	M2_I34A1 A4GXH7 Q20N37 Q5UAV4 Q5UAV5 Q5UAV6 Q84105 Q8JUU3
sequenceLength	97
species	[Species:9031716] Influenza A virus
(isoformParent)	[ReferenceIsoform:402525] UniProt:P06821-1 M [Influenza A virus]
(referenceEntity)	[EntityWithAccessionedSequence:169089] M2 [cytosol] [Influenza A virus] [EntityWithAccessionedSequence:189151] M2 [endosome lumen] [Influenza A virus] [EntityWithAccessionedSequence:189156] M2 [Influenza A virus] [EntityWithAccessionedSequence:195729] palmitylated M2 [plasma membrane] [Influenza A virus] [EntityWithAccessionedSequence:195741] palmitylated M2 [Golgi membrane] [Influenza A virus] [EntityWithAccessionedSequence:195756] M2 [endoplasmic reticulum membrane] [Influenza A virus] [EntityWithAccessionedSequence:195770] M2 [Golgi membrane] [Influenza A virus] [EntityWithAccessionedSequence:195773] M2 [endocytic vesicle membrane] [Influenza A virus] [EntityWithAccessionedSequence:196491] palmitylated M2 [extracellular region] [Influenza A virus]
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No pathways have been reviewed or authored by UniProt:P06821 M (169056)