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Details on Person The host cell mRNA bound to viral RNA polymerase PB2 subunit...

Class:IdSummation:168985
_displayNameThe host cell mRNA bound to viral RNA polymerase PB2 subunit...
_timestamp2007-04-09 18:37:21
created[InstanceEdit:168988] D'Eustachio, P, 2005-11-22 21:19:36
literatureReference[LiteratureReference:192784] Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins
[LiteratureReference:192737] RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites
[LiteratureReference:169009] Selected host cell capped RNA fragments prime influenza viral RNA transcription in vivo
[LiteratureReference:192887] Molecular dissection of influenza virus RNA polymerase: PB1 subunit alone is able to catalyze RNA synthesis
modified[InstanceEdit:170719] D'Eustachio, P, 2006-01-13 15:29:50
[InstanceEdit:192929] 2007-04-09 15:04:30
[InstanceEdit:195637] Gillespie, ME, 2007-04-09 18:37:11
textThe host cell mRNA bound to viral RNA polymerase PB2 subunit is cleaved by the viral RNA polymerase PB1 subunit's endonuclease activity, and the capped 5' end plus 10-13 nucleotides of the host mRNA remains bound to the polymerase complex (Plotch, 1981; Krug, 1981; Hagen, 1994; Cianci, 1995, Li, 1998; Li, 2001). Viral mRNA may be protected against cap-snatching by the polymerase complex itself, which tightly binds capped viral mRNA (Shih, 1996). A guanine residue, complementary to a cytosine in the vRNA, is added to the host-derived cap, catalyzed by the RNA polymerase activity of the PB1 viral RNA polymerase subunit (Beaton, 1981; Toyoda, 1986).
(summation)[Reaction:168280] Priming and Initiation of Transcription [Homo sapiens]
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