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Details on Person TLR1:TLR2 is recruited to ligand:CD14

Class:Id	Reaction:168951
_displayName	TLR1:TLR2 is recruited to ligand:CD14
_doRelease	TRUE
_timestamp	2016-11-10 00:55:42
authored	[InstanceEdit:179395] D'Eustachio, P, Gay, NJ, Gale M, Jr, Zwaginga, JJ, 2006-04-19 04:09:58
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:168943] de Bono, B, 2005-11-22 18:44:27
edited	[InstanceEdit:2603251] Shamovsky, V, 2012-11-19
input	[Complex:168946] TLR1:TLR2 [plasma membrane] [Homo sapiens] [Complex:2559462] TLR1:TLR2 ligand:CD14 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:180828] Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 [LiteratureReference:180969] Inferences, questions and possibilities in Toll-like receptor signalling [LiteratureReference:180792] Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling
modified	[InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177804] Gillespie, ME, 2006-04-07 03:21:26 [InstanceEdit:181223] de Bono, B, 2006-06-08 12:06:48 [InstanceEdit:181228] de Bono, B, 2006-06-08 12:21:07 [InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:181964] de Bono, B, 2006-07-04 10:36:47 [InstanceEdit:182627] de Bono, B, 2006-07-11 10:20:29 [InstanceEdit:182631] de Bono, B, 2006-07-11 11:29:15 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:1018388] Shamovsky, V, 2010-11-16 [InstanceEdit:1020101] Shamovsky, V, 2010-11-16 [InstanceEdit:1094899] Shamovsky, V, 2010-11-29 [InstanceEdit:1095196] Shamovsky, V, 2010-11-30 [InstanceEdit:2559480] Shamovsky, V, 2012-11-02 [InstanceEdit:2629678] Shamovsky, V, 2012-11-20 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLR1:TLR2 is recruited to ligand:CD14
output	[Complex:181226] TLR1:TLR2:TLR1/2 ligand:CD14 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2559468] TLR1/2 ligand binds to CD14 [Homo sapiens]
regulatedBy	[NegativeRegulation:5432890] Negative regulation by 'SFTPA oligomer, SFTPD oligomer [extracellular region]'
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2005-06-13
reviewed	[InstanceEdit:181939] D'Eustachio, P, 2006-07-03 21:35:13 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362016] R-HSA-168951.4
summation	[Summation:181957] The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobac...
(hasEvent)	[Pathway:168179] Toll Like Receptor TLR1:TLR2 Cascade [Homo sapiens]
(precedingEvent)	[Reaction:2201316] Activated TLR2/4 interacts with MAL (TIRAP) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786654] Update Tracker - [Reaction:168951] TLR1:TLR2 is recruited to ligand:CD14 - v49:[addRegulator] [_UpdateTracker:9788289] Update Tracker - [Reaction:168951] TLR1:TLR2 is recruited to ligand:CD14 - v43:[add_removeInput]
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No pathways have been reviewed or authored by TLR1:TLR2 is recruited to ligand:CD14 (168951)