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Details on Person viral dsRNA binds DDX58

Class:Id	Reaction:168935
_displayName	viral dsRNA binds DDX58
_doRelease	TRUE
_timestamp	2017-12-01 23:37:15
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[EntityWithAccessionedSequence:168917] DDX58 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168917] DDX58 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [DefinedSet:9013905] DDX58 ligand [cytosol] [Hepatitis C Virus] [DefinedSet:9013905] DDX58 ligand [cytosol] [Hepatitis C Virus]
literatureReference	[LiteratureReference:168671] The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses [LiteratureReference:936495] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
modified	[InstanceEdit:177474] Gopinathrao, G, 2006-03-30 18:08:55 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177726] Gillespie, ME, 2006-04-04 13:34:42 [InstanceEdit:177804] Gillespie, ME, 2006-04-07 03:21:26 [InstanceEdit:177884] Gillespie, ME, 2006-04-11 02:04:55 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:913723] Garapati, P V, 2010-07-19 [InstanceEdit:918223] Garapati, P V, 2010-08-02 [InstanceEdit:936502] Garapati, P V, 2010-08-23 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1028822] Garapati, P V, 2010-11-18 [InstanceEdit:1964487] Shamovsky, V, 2011-11-04 [InstanceEdit:5617437] Gillespie, Marc E, 2014-08-08 [InstanceEdit:6790582] Shamovsky, Veronica, 2015-08-13 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9013941] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	viral dsRNA binds DDX58 dsRNA binds to RIG-I
output	[Complex:168906] 2x DDX58 ligand:2x DDX58:2xATP [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1964482] RNA polymerase III transcribes microbial dsDNA to dsRNA [Homo sapiens]
regulatedBy	[NegativeRegulation:937345] Negative regulation by 'DHX58 [cytosol]' [NegativeRegulation:992763] Negative regulation by 'ISG15:DDX58 conjugate [cytosol]'
relatedSpecies	[Species:5617433] Rotavirus [Species:5621375] Hepatitis C Virus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105771] R-HSA-168935.8
summation	[Summation:177850] Probable ATP-dependent RNA helicase DDX58 (DDX58, RIG-I, RIG... [Summation:936538] ISG15 is an ubiquitin (Ub)-like protein which is conjugated ... [Summation:937332] LGP2 acts as a natural negative regulator of dsRNA signaling...
(hasEvent)	[Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta [Homo sapiens]
(precedingEvent)	[Reaction:918224] DDX58 is K63 polyubiquitinated [Homo sapiens] [Reaction:9733680] YWHAE binds DDX58 and TRIM25 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775556] Update Tracker - [Reaction:168935] viral dsRNA binds DDX58 - v78:[addSummation] [_UpdateTracker:9780548] Update Tracker - [Reaction:168935] viral dsRNA binds DDX58 - v62:[add_removeInput] [_UpdateTracker:9781183] Update Tracker - [Reaction:168935] viral dsRNA binds DDX58 - v61:[modifyText] [_UpdateTracker:9784054] Update Tracker - [Reaction:168935] viral dsRNA binds DDX58 - v54:[add_removeInput] [_UpdateTracker:9928501] Update Tracker - [Reaction:168935] viral dsRNA binds DDX58 - v91:[modifyText]
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