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Details on Person Dimerization of phosphorylated IRF3/IRF7

Class:Id	Reaction:168933
_displayName	Dimerization of phosphorylated IRF3/IRF7
_doRelease	TRUE
_timestamp	2012-11-20 17:30:50
authored	[InstanceEdit:450360] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:434040] X-ray crystal structure of IRF-3 and its functional implications
modified	[InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:177912] Gillespie, ME, 2006-04-11 02:48:37 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450360] Shamovsky, V, 2009-12-16 [InstanceEdit:500512] Shamovsky, V, 2010-02-04 [InstanceEdit:525804] Shamovsky, V, 2010-02-22 [InstanceEdit:525841] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:933545] Garapati, P V, 2010-08-16 [InstanceEdit:937089] Shamovsky, V, 2010-08-25 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1095194] Shamovsky, V, 2010-11-30 [InstanceEdit:1564946] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632485] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of phosphorylated IRF3/IRF7
output	[DefinedSet:450256] phosphorylated IRF3 and/or IRF7 dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:168903] Phosphorylation and Release of IRF3 or IRF7 [Homo sapiens] [Reaction:918229] Phosphorylation and release of IRF3/IRF7 [Homo sapiens] [Reaction:918232] Recruitment of IRF3,IRF7 [Homo sapiens] [Reaction:166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex [Homo sapiens] [Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360544] R-HSA-168933.2
summation	[Summation:433793] Phosphorylation results in IRF-3 dimerization and removal of...
(hasEvent)	[Pathway:168936] Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon [Homo sapiens] [Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens] [Pathway:9013973] TICAM1-dependent activation of IRF3/IRF7 [Homo sapiens]
(inferredFrom)	[Reaction:434027] Dimerization of Phospho-IRF3 [Gallus gallus]
(precedingEvent)	[Reaction:177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790941] Update Tracker - [Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
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