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Details on Person Viral dsRNA:TLR3 recruits TRIF (TICAM1)

Class:IdReaction:168929
_displayNameViral dsRNA:TLR3 recruits TRIF (TICAM1)
_doReleaseTRUE
_timestamp2017-12-01 23:36:58
authored[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited[InstanceEdit:450360] Shamovsky, V, 2009-12-16
input[EntityWithAccessionedSequence:166170] TICAM1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:166170] TICAM1 [cytosol] [Homo sapiens]
[Complex:167985] viral dsRNA :TLR3 [endosome membrane] [Homo sapiens]
literatureReference[LiteratureReference:434112] TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
[LiteratureReference:177881] Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
[LiteratureReference:165909] LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters
modified[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:177522] Gillespie, ME, 2006-03-31 20:24:36
[InstanceEdit:177884] Gillespie, ME, 2006-04-11 02:04:55
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:450362] Shamovsky, V, 2009-12-16
[InstanceEdit:500573] Shamovsky, V, 2010-02-04
[InstanceEdit:525853] Shamovsky, V, 2010-02-22
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
[InstanceEdit:1008271] Shamovsky, V, 2010-11-10
[InstanceEdit:2559491] Shamovsky, V, 2012-11-02
[InstanceEdit:2582979] Shamovsky, V, 2012-11-13
[InstanceEdit:2632487] Shamovsky, V, 2012-11-20
[InstanceEdit:2632490] Shamovsky, V, 2012-11-20
[InstanceEdit:3621903] Shamovsky, V, 2013-05-24
[InstanceEdit:9013880] Shamovsky, Veronica, 2017-07-26
[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameViral dsRNA:TLR3 recruits TRIF (TICAM1)
output[Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361340] R-HSA-168929.4
summation[Summation:450288] TIR-domain-containing adaptor inducing interferon-beta (TRIF...
(hasEvent)[Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade [Homo sapiens]
(inferredFrom)[Reaction:433815] viral dsRNA : TRL3 recruits TICAM1 [Gallus gallus]
(normalReaction)[FailedReaction:5602712] TICAM1 deficiency blocks TLR3 pathway [Homo sapiens]
(precedingEvent)[Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 [Homo sapiens]
[Reaction:177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 [Homo sapiens]
[Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 [Homo sapiens]
[Reaction:9013992] TRAF3 binds to TRIF:activated TLR3 complex [Homo sapiens]
[Reaction:9014320] SARM binds viral dsRNA:TLR3:TICAM1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788188] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v43:[modifyText]
[_UpdateTracker:9788664] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v41:[modifyText]
[_UpdateTracker:9789210] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v38:[modifyText]
[_UpdateTracker:9789588] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v37:[modifyText]
[_UpdateTracker:9790076] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v35:[modifyText]
[_UpdateTracker:9791155] Update Tracker - [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - v32:[addLiteratureReference, add_removeSummation]
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