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Details on Person DDX58 [cytosol]
Class:Id EntityWithAccessionedSequence:168917
_displayName DDX58 [cytosol]
_timestamp 2013-02-07 19:46:38
compartment [Compartment:70101] cytosol
created [InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
endCoordinate 925
literatureReference [LiteratureReference:168671] The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
modified [InstanceEdit:2871602] Jupe, S, 2012-12-21 [InstanceEdit:3027889] D'Eustachio, P, 2013-02-05 [InstanceEdit:3080569] D'Eustachio, P, 2013-02-07
name DDX58 RIG-I
referenceEntity [ReferenceGeneProduct:168340] UniProt:O95786 RIGI [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1109073] R-HSA-168917.1
startCoordinate 1
(hasCandidate) [CandidateSet:1169379] ISG15 targets [cytosol] [Homo sapiens]
(hasComponent) [Complex:168906] 2x DDX58 ligand:2x DDX58:2xATP [cytosol] [Homo sapiens] [Complex:936557] ISG15:DDX58 conjugate [cytosol] [Homo sapiens] [Complex:6782841] USP25:DDX58 [cytosol] [Homo sapiens] [Complex:8985113] OASL:DDX58 [cytosol] [Homo sapiens] [Complex:9704989] SARS-CoV-1 dsRNA intermediates:DDX58:ATP [double membrane vesicle viral factory outer membrane] [Homo sapiens] [Complex:9717522] DDX58:NS2 [cytosol] [Homo sapiens] [Complex:9717601] 2xZCCHC3:2x DDX58 ligand:2x DDX58:2xATP [cytosol] [Homo sapiens] [Complex:9717677] DDX58:N [cytosol] [Homo sapiens] [Complex:9717686] DDX58:UL37 [cytosol] [Homo sapiens] [Complex:9733870] DDX58:RL1 [cytosol] [Homo sapiens]
(hasMember) [DefinedSet:936436] DDX58, IFIH1 [cytosol] [Homo sapiens] [DefinedSet:5690188] RIPK1, DDX58 [cytosol] [Homo sapiens] [DefinedSet:5696897] RCE1, CDC25A, DDX58, IFIH1 [cytosol] [Homo sapiens] [DefinedSet:6782842] TRAF2,TRAF6,DDX58 [cytosol] [Homo sapiens] [DefinedSet:8962899] Proteins overexpressed after IL27 stimulation [cytosol] [Homo sapiens]
(input) [Reaction:168935] viral dsRNA binds DDX58 [Homo sapiens] [Reaction:936563] ISGylation of DDX58 [Homo sapiens] [Reaction:8985153] OASL binds DDX58 [Homo sapiens] [Reaction:9693589] SARS-CoV-1 dsRNA intermediates bind DDX58 [Homo sapiens] [Reaction:9717469] NS2 (1B) binds DDX58 [Homo sapiens] [Reaction:9717585] PRKCA, PRKCB phosphorylate DDX58 [Homo sapiens] [Reaction:9717626] ZCCHC3 binds viral dsRNA and DDX58 [Homo sapiens] [Reaction:9717658] SARS-CoV-2 N binds DDX58 [Homo sapiens] [Reaction:9717685] HHV-1 UL37 binds DDX58 [Homo sapiens] [Reaction:9717945] CK2 phosphorylates DDX58 [Homo sapiens]
(output) [BlackBoxEvent:936390] CYLD mediated deubiquitination of DDX58 (RIG-I) [Homo sapiens] [Reaction:9717588] Dephosphorylation of DDX58 [Homo sapiens] [Reaction:9717952] HDAC6 deacetylates DDX58 [Homo sapiens]
(updatedInstance) [_UpdateTracker:9877632] Update Tracker - [EntityWithAccessionedSequence:168917] DDX58 [cytosol] - v44:[addEndCoordinate, addName, addStartCoordinate]
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No pathways have been reviewed or authored by DDX58 [cytosol] (168917)