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Details on Person RIP1 facilitates IKK complex phosphorylation

Class:IdReaction:168910
_displayNameRIP1 facilitates IKK complex phosphorylation
_doReleaseTRUE
_timestamp2012-07-19 15:43:58
authored[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input[SimpleEntity:113592] ATP [cytosol]
[Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
[LiteratureReference:434140] IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
[LiteratureReference:434149] The nemo binding domains of both IKKalpha and IKKbeta regulate IKK complex assembly and classical NFkappaB activation
[LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity
modified[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:177650] Gillespie, ME, 2006-04-03 18:36:10
[InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17
[InstanceEdit:177884] Gillespie, ME, 2006-04-11 02:04:55
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:194318] de Bono, B, 2007-03-13 13:58:14
[InstanceEdit:450361] Shamovsky, V, 2009-12-16
[InstanceEdit:500559] Shamovsky, V, 2010-02-04
[InstanceEdit:525849] Shamovsky, V, 2010-02-22
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
[InstanceEdit:975224] Shamovsky, V, 2010-09-22
[InstanceEdit:975230] Shamovsky, V, 2010-09-22
[InstanceEdit:975233] Shamovsky, V, 2010-09-22
[InstanceEdit:1008271] Shamovsky, V, 2010-11-10
[InstanceEdit:1013048] Shamovsky, V, 2010-11-12
[InstanceEdit:1014290] Shamovsky, V, 2010-11-15
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1564970] Shamovsky, V, 2011-09-06
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:1810478] Shamovsky, V, 2011-10-25
[InstanceEdit:2008119] Shamovsky, V, 2011-11-21
[InstanceEdit:2129343] Shamovsky, V, 2012-02-19
[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
[InstanceEdit:2408498] Shamovsky, V, 2012-07-17
[InstanceEdit:2422453] Shamovsky, V, 2012-07-19
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRIP1 facilitates IKK complex phosphorylation
output[SimpleEntity:29370] ADP [cytosol]
[Complex:177663] IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:975228] Positive regulation by 'viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]'
[PositiveRegulation:1810459] Positive regulation by 'dsDNA:ZBP1:RIP1:RIP3 [cytosol]'
releaseDate2010-12-14
reviewed[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07
[InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359700] R-HSA-168910.3
summation[Summation:450244] In humans, the IkB kinase (IKK) complex serves as the master...
[Summation:939839] RIP1 polyubiquitination was induced upon TNF- or poly(I-C) t...
(hasEvent)[Pathway:1810476] RIP-mediated NFkB activation via ZBP1 [Homo sapiens]
(inferredFrom)[Reaction:433845] chicken RIP1 facilitates IKKs complex activation [Gallus gallus]
(precedingEvent)[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens]
(replacementInstances)[_Deleted:765400] Deletion of instance: 168911
(updatedInstance)[_UpdateTracker:9774841] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v81:[modifyText]
[_UpdateTracker:9775042] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v80:[modifyText]
[_UpdateTracker:9788303] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v43:[modifyText]
[_UpdateTracker:9788913] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v39:[addRegulator]
[_UpdateTracker:9789178] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v38:[removeCatalystActivity]
[_UpdateTracker:9790132] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v35:[addRegulator, addSummation, add_removeCatalystActivity, modifyText]
[_UpdateTracker:9790216] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v34:[modifyText]
[_UpdateTracker:9791086] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v32:[add_removeLiteratureReference, add_removeSummation]
[_UpdateTracker:9792445] Update Tracker - [Reaction:168910] RIP1 facilitates IKK complex phosphorylation - v21:[removeCatalystActivity]
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