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Details on Person viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

Class:Id	Reaction:168909
_displayName	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
_doRelease	TRUE
_timestamp	2024-11-15 06:10:42
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[EntityWithAccessionedSequence:913730] MAVS [mitochondrial outer membrane] [Homo sapiens] [DefinedSet:918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:177847] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction [LiteratureReference:918219] Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain [LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling [LiteratureReference:1227961] Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
modified	[InstanceEdit:177474] Gopinathrao, G, 2006-03-30 18:08:55 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177727] Gillespie, ME, 2006-04-04 13:34:45 [InstanceEdit:177804] Gillespie, ME, 2006-04-07 03:21:26 [InstanceEdit:177884] Gillespie, ME, 2006-04-11 02:04:55 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:918223] Garapati, P V, 2010-08-02 [InstanceEdit:933522] Garapati, P V, 2010-08-16 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1227960] Garapati, P V, 2011-03-14 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9013953] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9715437] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716565] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835855] Shamovsky, Veronica, 2023-05-18 [InstanceEdit:9927388] Shamovsky, Veronica, 2024-11-05 [InstanceEdit:9927536] Shamovsky, Veronica, 2024-11-07 [InstanceEdit:9927963] Shamovsky, Veronica, 2024-11-10 [InstanceEdit:9928382] Matthews, Lisa, 2024-11-15
name	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS RIG-I/MDA5 interacts with IPS-1
output	[Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[Reaction:918224] DDX58 is K63 polyubiquitinated [Homo sapiens] [Reaction:168935] viral dsRNA binds DDX58 [Homo sapiens] [Reaction:913725] viral dsRNA binds IFIH1:TKFC [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:992760] Negative regulation by 'MAVS:NLRX1 [mitochondrial outer membrane]' [NegativeRegulation:992762] Negative regulation by 'viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]'
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:5617433] Rotavirus [Species:9013948] Measles virus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30 [InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104212] R-HSA-168909.9
structureModified	[InstanceEdit:9927388] Shamovsky, Veronica, 2024-11-05 [InstanceEdit:9927963] Shamovsky, Veronica, 2024-11-10
summation	[Summation:177874] Upon binding viral dsRNA, Probable ATP-dependent RNA helicas... [Summation:937331] NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom... [Summation:936543] NLRX1 is a member of nucleotide-binding domain and leucine-r...
(hasEvent)	[Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta [Homo sapiens]
(inferredFrom)	[Reaction:1227709] Activated MDA5 binds IPS-1 [Gallus gallus]
(precedingEvent)	[Reaction:168934] MAVS interacts with RIPK1 and FADD [Homo sapiens] [Reaction:918227] Recruitment of TRAF3 to MAVS [Homo sapiens] [Reaction:990528] Interaction of PCBP2 with MAVS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775532] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v78:[addSummation] [_UpdateTracker:9780905] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v61:[modifyText] [_UpdateTracker:9789676] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v37:[addLiteratureReference] [_UpdateTracker:9928436] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v91:[modifyText]
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No pathways have been reviewed or authored by viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (168909)