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Details on Person Phosphorylation and Release of IRF3 or IRF7

Class:Id	Reaction:168903
_displayName	Phosphorylation and Release of IRF3 or IRF7
_doRelease	FALSE
_timestamp	2017-02-27 15:37:52
authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:177658] protein serine/threonine kinase activity of unknown entity
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
edited	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:433975] Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical [LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch
modified	[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:177908] Gillespie, ME, 2006-04-11 02:48:25 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450361] Shamovsky, V, 2009-12-16 [InstanceEdit:500557] Shamovsky, V, 2010-02-04 [InstanceEdit:525847] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2457719] Shamovsky, V, 2012-08-28 [InstanceEdit:3371603] Shamovsky, V, 2013-05-13 [InstanceEdit:3371604] Shamovsky, V, 2013-05-13 [InstanceEdit:3371605] Shamovsky, V, 2013-05-13 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8979781] Shamovsky, Veronica, 2017-02-27
name	Phosphorylation and Release of IRF3 or IRF7
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens] [DefinedSet:450240] p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8920545] R-HSA-168903.1
summation	[Summation:450284] Human IRF-3 is activated through a two step phosphorylation ...
(hasEvent)	[Pathway:168936] Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon [Homo sapiens]
(precedingEvent)	[Reaction:168933] Dimerization of phosphorylated IRF3/IRF7 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790028] Update Tracker - [Reaction:168903] Phosphorylation and Release of IRF3 or IRF7 - v35:[modifyText] [_UpdateTracker:9790897] Update Tracker - [Reaction:168903] Phosphorylation and Release of IRF3 or IRF7 - v32:[addLiteratureReference, add_removeOutput, add_removeSummation]
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No pathways have been reviewed or authored by Phosphorylation and Release of IRF3 or IRF7 (168903)