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Details on Person Activated TAK1 mediates phosphorylation of the IKK Complex

Class:Id	Reaction:168184
_displayName	Activated TAK1 mediates phosphorylation of the IKK Complex
_doRelease	TRUE
_timestamp	2022-05-18 13:21:32
authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:177696] protein serine/threonine kinase activity of Activated TAK complexes [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
edited	[InstanceEdit:450360] Shamovsky, V, 2009-12-16
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:169969] Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death [LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK [LiteratureReference:2685059] Signal-induced ubiquitination of I kappaB Kinase-beta [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:2685119] The IKK complex, a central regulator of NF-kappaB activation
modified	[InstanceEdit:170020] Gillespie, ME, 2005-12-19 05:16:24 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177701] Gillespie, ME, 2006-04-04 05:54:07 [InstanceEdit:177904] Gillespie, ME, 2006-04-11 02:47:44 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450360] Shamovsky, V, 2009-12-16 [InstanceEdit:500472] Shamovsky, V, 2010-02-04 [InstanceEdit:525840] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:772535] Jupe, S, 2010-05-21 [InstanceEdit:844609] Jupe, S, 2010-05-28 [InstanceEdit:847075] Shamovsky, V, 2010-05-28 [InstanceEdit:847735] Shamovsky, V, 2010-06-01 [InstanceEdit:937083] Shamovsky, V, 2010-08-25 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1014262] Shamovsky, V, 2010-11-15 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1361857] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2603256] Shamovsky, V, 2012-11-19 [InstanceEdit:2632484] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:9014306] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9014565] Shamovsky, Veronica, 2017-08-01 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9645613] Shamovsky, Veronica, 2019-05-13 [InstanceEdit:9765918] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9768017] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9773674] Shamovsky, Veronica, 2022-05-09 [InstanceEdit:9773777] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9773812] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9774120] Shamovsky, Veronica, 2022-05-17 [InstanceEdit:9774130] Matthews, Lisa, 2022-05-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TAK1 mediates phosphorylation of the IKK Complex
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [Homo sapiens]
precedingEvent	[Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [Reaction:177692] Activation of recruited TAK1 within the activated TLR3 complex [Homo sapiens] [BlackBoxEvent:706479] TAK1 is activated [Homo sapiens] [Reaction:688985] K63 polyubiquitinated RIP2 associates with the TAK1 complex [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens] [Reaction:9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex [Homo sapiens] [Reaction:9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) [Homo sapiens] [Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens]
regulatedBy	[PositiveRegulation:9765922] Positive regulation by 'N:TAK1complex [cytosol]' [PositiveRegulation:9765919] Positive regulation by 'N:CHUK:IKBKB:IKBKG [cytosol]'
regulationReference	[RegulationReference:9765920] Positive regulation by 'N:TAK1complex [cytosol]' RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation [RegulationReference:9765921] Positive regulation by 'N:CHUK:IKBKB:IKBKG [cytosol]' RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation
releaseDate	2010-12-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18 [InstanceEdit:9773242] de Martin, R, 2022-05-04
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361516] R-HSA-168184.7
summation	[Summation:450244] In humans, the IkB kinase (IKK) complex serves as the master...
(hasEvent)	[Pathway:168638] NOD1/2 Signaling Pathway [Homo sapiens] [Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation [Homo sapiens] [Pathway:9020702] Interleukin-1 signaling [Homo sapiens] [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
(inferredFrom)	[Reaction:433955] Phosphorylation of IKKs complex by activated TAK1 [Gallus gallus] [Reaction:1168641] TAK1 associated with the CBM complex phosphorylates IKKbeta [Homo sapiens]
(precedingEvent)	[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens] [Reaction:5684261] MAP3K8 is phosphorylated [Homo sapiens] [Reaction:5684267] IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex [Homo sapiens] [Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 [Homo sapiens] [Reaction:9749471] NLRX1 binds CHUK:IKBKB:IKBKG [Homo sapiens] [Reaction:9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor [Homo sapiens] [Reaction:9860292] Activated IKBKB phosphorylates IRF5 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774744] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v81:[addLiteratureReference, add_removeOutput, modifyText] [_UpdateTracker:9775261] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v80:[addRegulator, modifyText] [_UpdateTracker:9788215] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v43:[modifyText] [_UpdateTracker:9790093] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v35:[modifyText] [_UpdateTracker:9790203] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v34:[modifyText] [_UpdateTracker:9790969] Update Tracker - [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex - v32:[addLiteratureReference, add_removeSummation]
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