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Details on Person Phosphorylation of human JNKs by activated MKK4/MKK7

Class:Id	Reaction:168162
_displayName	Phosphorylation of human JNKs by activated MKK4/MKK7
_doRelease	TRUE
_timestamp	2017-02-28 17:01:45
authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:450334] JUN kinase kinase activity of p-MAP2K4/p-MAP2K7 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
edited	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
input	[SimpleEntity:113592] ATP [cytosol] [DefinedSet:450289] MAPK8,9,10 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:169962] Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. [LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses [LiteratureReference:444056] Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
modified	[InstanceEdit:168958] de Bono, B, 2005-11-22 19:13:18 [InstanceEdit:170020] Gillespie, ME, 2005-12-19 05:16:24 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177705] Gillespie, ME, 2006-04-04 05:54:41 [InstanceEdit:177841] Gillespie, ME, 2006-04-11 01:16:00 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:353084] Gillespie, ME, 2008-06-10 20:16:38 [InstanceEdit:450361] Shamovsky, V, 2009-12-16 [InstanceEdit:500558] Shamovsky, V, 2010-02-04 [InstanceEdit:525848] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:2730898] Garapati, P V, 2012-12-05 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:8980648] Duenas, Corina, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of human JNKs by activated MKK4/MKK7
output	[SimpleEntity:29370] ADP [cytosol] [DefinedSet:450226] p-MAPK8,9,10 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens] [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:2730868] Phosphorylation of MEK7 by MEKK1 [Homo sapiens] [Reaction:2730887] Autophosphorylation and activation of MEKK1 [Homo sapiens] [BlackBoxEvent:8980352] TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6 [Homo sapiens] [BlackBoxEvent:8980347] miRNA-23b upregulated after NFKB activation by IL17-IL17R interaction [Homo sapiens] [Reaction:8980295] Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359662] R-HSA-168162.3
summation	[Summation:450223] Activated human JNK kinases (MKK4 and MKK7) phosphorylate T...
(hasEvent)	[Pathway:450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [Homo sapiens] [Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(inferredFrom)	[Reaction:438005] MKK4 phosphorylates JNK [Gallus gallus]
(precedingEvent)	[Reaction:450348] Activated human JNKs migrate to nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790911] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, add_removeSummation] [_UpdateTracker:9791789] Update Tracker - [Reaction:168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - v25:[add_removeOutput]
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