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Details on Person Active IKK Complex phosphorylates NF-kappa-B inhibitor

Class:Id	Reaction:168140
_displayName	Active IKK Complex phosphorylates NF-kappa-B inhibitor
_doRelease	TRUE
_timestamp	2022-05-17 15:10:53
catalystActivity	[CatalystActivity:450351] protein serine/threonine kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
edited	[InstanceEdit:450363] Shamovsky, V, 2009-12-16
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:177888] Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:9630958] Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB
modified	[InstanceEdit:168958] de Bono, B, 2005-11-22 19:13:18 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46 [InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10 [InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:177707] Gillespie, ME, 2006-04-04 05:55:00 [InstanceEdit:177909] Gillespie, ME, 2006-04-11 02:48:28 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:450361] Shamovsky, V, 2009-12-16 [InstanceEdit:500555] Shamovsky, V, 2010-02-04 [InstanceEdit:525845] Shamovsky, V, 2010-02-22 [InstanceEdit:532463] Shamovsky, V, 2010-02-27 [InstanceEdit:622345] Jupe, S, 2010-04-23 [InstanceEdit:2129343] Shamovsky, V, 2012-02-19 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2603281] Shamovsky, V, 2012-11-19 [InstanceEdit:2632486] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5633399] Matthews, Lisa, 2014-10-31 [InstanceEdit:9038738] Orlic-Milacic, Marija, 2018-03-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9630955] Shamovsky, Veronica, 2018-12-03 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9757934] Shamovsky, Veronica, 2021-11-05 [InstanceEdit:9761369] Shamovsky, Veronica, 2022-01-13 [InstanceEdit:9773241] Shamovsky, Veronica, 2022-05-04 [InstanceEdit:9773709] Shamovsky, Veronica, 2022-05-09 [InstanceEdit:9773734] Shamovsky, Veronica, 2022-05-09 [InstanceEdit:9774123] Shamovsky, Veronica, 2022-05-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active IKK Complex phosphorylates NF-kappa-B inhibitor
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [Homo sapiens] [DefinedSet:177678] Phospho-NF-kappaB Inhibitor [cytosol] [Homo sapiens]
precedingEvent	[Reaction:168910] RIP1 facilitates IKK complex phosphorylation [Homo sapiens] [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 [Homo sapiens] [Reaction:1810457] ZBP1(DAI) recruits RIP1 and RIP3 [Homo sapiens] [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [BlackBoxEvent:706479] TAK1 is activated [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex [Homo sapiens] [Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens] [Reaction:933530] Activation of IKK by MEKK1 [Homo sapiens] [Reaction:933528] Interaction of MEKK1 with TRAF6 [Homo sapiens] [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex [Homo sapiens]
regulatedBy	[NegativeRegulation:8952695] Negative regulation by 'NKIRAS [cytosol]'
regulationReference	[RegulationReference:9641502] Negative regulation by 'NKIRAS [cytosol]' KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes
releaseDate	2010-03-16
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358626] R-HSA-168140.8
summation	[Summation:450273] In human, IkBs (NFKBIA, NFKBIB or NFKBIE) are inhibitory pro...
systematicName	Activated IKK Complex phosphorylates IkBs:NFkB
(hasEvent)	[Pathway:933542] TRAF6 mediated NF-kB activation [Homo sapiens] [Pathway:1810476] RIP-mediated NFkB activation via ZBP1 [Homo sapiens] [Pathway:8852558] Transcriptional Regulation by the NFKB Complex [Homo sapiens]
(normalReaction)	[FailedReaction:5262865] IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR) [Homo sapiens]
(precedingEvent)	[Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus [Homo sapiens] [Reaction:9604480] NFkB complex translocates from the cytosol to the nucleus [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774822] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v81:[modifyText] [_UpdateTracker:9775251] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v80:[modifyText] [_UpdateTracker:9777883] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v68:[addLiteratureReference] [_UpdateTracker:9781856] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v60:[addRegulator] [_UpdateTracker:9788855] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v40:[modifyText] [_UpdateTracker:9791005] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeSummation]
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