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Details on Person Activated JNKs phosphorylate c-JUN

Class:IdReaction:168136
_displayNameActivated JNKs phosphorylate c-JUN
_doReleaseTRUE
_timestamp2020-01-09 14:58:35
authored[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity[CatalystActivity:450228] JUN kinase activity of p-MAPK8,9,10 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
edited[InstanceEdit:450360] Shamovsky, V, 2009-12-16
input[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:450250] JUN [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:169974] c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity
[LiteratureReference:437979] c-Jun expression, activation and function in neural cell death, inflammation and repair
modified[InstanceEdit:170020] Gillespie, ME, 2005-12-19 05:16:24
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177475] Gopinathrao, G, 2006-03-30 20:13:46
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:177704] Gillespie, ME, 2006-04-04 05:54:33
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:216362] Jassal, B, 2008-03-14 11:00:22
[InstanceEdit:450360] Shamovsky, V, 2009-12-16
[InstanceEdit:500471] Shamovsky, V, 2010-02-04
[InstanceEdit:525839] Shamovsky, V, 2010-02-22
[InstanceEdit:532463] Shamovsky, V, 2010-02-27
[InstanceEdit:1008271] Shamovsky, V, 2010-11-10
[InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:9673290] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673432] Murillo, Julieth, 2020-01-07
[InstanceEdit:9673793] Murillo, Julieth, 2020-01-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated JNKs phosphorylate c-JUN
output[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
[EntityWithAccessionedSequence:450237] p-S63,S73-JUN [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450323] Shamovsky, V, 2009-12-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105311] R-HSA-168136.3
summation[Summation:169953] JNK (c-Jun N-terminal Kinase) phosphorylates several transcr...
(hasEvent)[Pathway:450341] Activation of the AP-1 family of transcription factors [Homo sapiens]
[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
[Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(inferredFrom)[Reaction:438026] Activation and dimerization of c-JUN in the nucleus [Gallus gallus]
(precedingEvent)[BlackBoxEvent:168193] Transcriptional action of c-Jun-P and ATF-2-P induce IFNB [Homo sapiens]
[BlackBoxEvent:168197] Transcriptional action of c-Jun-P and ATF-1-P induce IFNA [Homo sapiens]
[Reaction:168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. [Homo sapiens]
[Reaction:450292] Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. [Homo sapiens]
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