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Details on Person NFkB inhibitor:NFkB complex [cytosol]

Class:Id	Complex:168130
_displayName	NFkB inhibitor:NFkB complex [cytosol]
_timestamp	2018-12-03 21:30:46
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
hasComponent	[Complex:168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168172] RELA [cytosol] [Homo sapiens] [DefinedSet:177656] NFKB1(1-433), NFKB2(1-454) [cytosol] [Homo sapiens] [DefinedSet:168143] NFkB inhibitor [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9630944] Structure of an IkappaBalpha/NF-kappaB complex
modified	[InstanceEdit:170425] Schmidt, EE, 2006-01-06 08:13:36 [InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:1495953] Shamovsky, V, 2011-08-16 [InstanceEdit:9630954] Shamovsky, Veronica, 2018-12-03
name	NFkB inhibitor:NFkB complex IkBs:NFkB
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362918] R-HSA-168130.2
(input)	[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens] [FailedReaction:5262865] IKK complex with defective NEMO (IKBKG) does not phosphorylate IkB within IkB:NF-kappaB (via TNFR) [Homo sapiens] [Reaction:9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9630951] loss_of_function of NFKBIA variants:NFkB complex [cytosol]
(output)	[Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9870752] Update Tracker - [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] - v38:[modifyName] [_UpdateTracker:9897542] Update Tracker - [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] - v62:[updateContainedComponent] [_UpdateTracker:9900158] Update Tracker - [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] - v68:[addLiteratureReference, addName, updateContainedComponent]
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No pathways have been reviewed or authored by NFkB inhibitor:NFkB complex [cytosol] (168130)