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Details on Person CHUK:IKBKB:IKBKG [cytosol]

Class:Id	Complex:168113
_displayName	CHUK:IKBKB:IKBKG [cytosol]
_timestamp	2017-02-27 13:54:21
authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
hasComponent	[EntityWithAccessionedSequence:168104] CHUK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168114] IKBKB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168108] IKBKG [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:937326] NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways [LiteratureReference:8867307] The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component [LiteratureReference:5607847] IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
modified	[InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:451558] Jupe, S, 2010-01-05 [InstanceEdit:1475441] May, B, 2011-08-09 [InstanceEdit:5633254] Matthews, Lisa, 2014-10-31 [InstanceEdit:8867305] Shamovsky, Veronica, 2016-04-06 [InstanceEdit:8979583] Duenas, Corina, 2017-02-27
name	CHUK:IKBKB:IKBKG IKKA:IKBKB:IKBKG IKK complex Inhibitor of KappaB kinase (IKK) Complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362457] R-HSA-168113.3
summation	[Summation:8867304] Co-immunoprecipitation studies and size exclusion chromatogr...
(hasComponent)	[Complex:451560] Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens] [Complex:933478] dsRNA:RIG-I/MDA5:TRAF2/TRAF6:IPS-1:RIP-1/FADD:Casp-8/10 prodomain:IKK complex [mitochondrial outer membrane] [Homo sapiens] [Complex:937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] [Homo sapiens] [Complex:975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] [Homo sapiens] [Complex:1168620] p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] [Homo sapiens] [Complex:5357936] TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] [Homo sapiens] [Complex:5626968] IKKA:IKKB:NEMO:RACK1 [cytosol] [Homo sapiens] [Complex:9014341] viral dsRNA:TLR3:TICAM1:K63pUb-RIP1:CHUK:IKBKB:IKBKG [endosome membrane] [Homo sapiens] [Complex:9749472] CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] [Homo sapiens] List all 14 refering instances
(input)	[Reaction:168109] Phosphorylated MEKK1 phosphorylates IKKs [Homo sapiens] [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:168910] RIP1 facilitates IKK complex phosphorylation [Homo sapiens] [Reaction:202500] Activation of IKK complex [Homo sapiens] [Reaction:451561] NEMO binds polyubiquitinated IRAK1 [Homo sapiens] [Reaction:933530] Activation of IKK by MEKK1 [Homo sapiens] [Reaction:933539] Recruitment of IKK complex [Homo sapiens] [Reaction:937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 [Homo sapiens] [Reaction:937032] NEMO subunit of IKK complex binds to activated IRAK1 [Homo sapiens] [Reaction:975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 [Homo sapiens] List all 26 refering instances
(output)	[Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens]
(physicalEntity)	[CatalystActivity:8863859] protein serine/threonine kinase activity of CHUK:IKBKB:IKBKG [cytosol]
(updatedInstance)	[_UpdateTracker:9869050] Update Tracker - [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] - v32:[addName] [_UpdateTracker:9870778] Update Tracker - [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] - v38:[addName] [_UpdateTracker:9894551] Update Tracker - [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] - v57:[addLiteratureReference, addSummation] [_UpdateTracker:9896679] Update Tracker - [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] - v60:[addName]
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No pathways have been reviewed or authored by CHUK:IKBKB:IKBKG [cytosol] (168113)