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Details on Person CHUK [cytosol]
Class:Id EntityWithAccessionedSequence:168104
_displayName CHUK [cytosol]
_timestamp 2015-09-14 16:25:47
compartment [Compartment:70101] cytosol
created [InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
endCoordinate 745
modified [InstanceEdit:168347] Gillespie, ME, 2005-11-17 04:14:45 [InstanceEdit:168347] Gillespie, ME, 2005-11-17 04:14:45 [InstanceEdit:177681] Gillespie, ME, 2006-04-03 21:05:17 [InstanceEdit:202512] Garapati, P V, 2007-10-31 11:22:38 [InstanceEdit:727818] Jupe, S, 2010-05-12 [InstanceEdit:2400004] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:5607626] Garapati, P V, 2014-07-14 [InstanceEdit:6797593] Orlic-Milacic, Marija, 2015-09-14
name CHUK IKKA IKK1 Inhibitor of nuclear factor kappa-B kinase alpha subunit
referenceEntity [ReferenceGeneProduct:57214] UniProt:O15111 CHUK [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:366499] R-HSA-168104.2
startCoordinate 1
(hasComponent) [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens] [Complex:202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] [Homo sapiens] [Complex:202562] CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] [Homo sapiens] [Complex:727820] Active IKK complex [cytosol] [Homo sapiens] [Complex:5262981] IKKA:IKKB:NEMO variant (TLR-mediated) [cytosol] [Homo sapiens] [Complex:5433023] IKKA:IKKB:NEMO variant (TLR-mediated) [cytosol] [Homo sapiens] [Complex:5607705] IKKA dimer [cytosol] [Homo sapiens] [Complex:9631802] CHUK:IKBKG:IKBKB Q432Pfs*62 [cytosol] [Homo sapiens] [Complex:9749465] CHUK:IKBKB:IKBIP [endoplasmic reticulum membrane] [Homo sapiens] [Complex:9749467] CHUK:IKBKB:LRRC14 [cytosol] [Homo sapiens]
(input) [Reaction:198611] AKT phosphorylates IKKalpha [Homo sapiens] [Reaction:2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) [Homo sapiens] [FailedReaction:5228840] Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG [Homo sapiens] [FailedReaction:5262921] Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) [Homo sapiens] [Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens] [Reaction:9749494] IKBIP binds IKBKB and CHUK [Homo sapiens] [Reaction:9749505] LRRC14 binds IKBKB and CHUK [Homo sapiens] [Reaction:9750226] NLRC5 binds IKBKB and CHUK [Homo sapiens]
(output) [BlackBoxEvent:9750946] TRAF2,6 ubiquitinates NLRC5 [Homo sapiens]
(updatedInstance) [_UpdateTracker:9873129] Update Tracker - [EntityWithAccessionedSequence:168104] CHUK [cytosol] - v42:[addEndCoordinate, addName, addStartCoordinate]
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Pathways
No pathways have been reviewed or authored by CHUK [cytosol] (168104)