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Details on Person PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
| Class:Id | LiteratureReference:1679952 |
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| _displayName | PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder |
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| _timestamp | 2011-10-20 20:14:56 |
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| author | [Person:1679945] Chen, J
[Person:1678877] Deangelo, DJ
[Person:983511] Kutok, JL
[Person:391137] Williams, IR
[Person:1678889] Lee, BH
[Person:1678897] Wadleigh, M
[Person:1678880] Duclos, N
[Person:1679942] Cohen, S
[Person:1678869] Adelsperger, J
[Person:1678891] Okabe, R
[Person:1678873] Coburn, A
[Person:1678884] Galinsky, I
[Person:1678887] Huntly, B
[Person:1678875] Cohen, PS
[Person:140033] Meyer, T
[Person:1678881] Fabbro, D
[Person:1678893] Roesel, J
[Person:1678871] Banerji, L
[Person:351525] Griffin, JD
[Person:1602273] Xiao, S
[Person:1602221] Fletcher, JA
[Person:1678895] Stone, RM
[Person:1678886] Gilliland, DG |
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| created | [InstanceEdit:1679953] Rothfels, K, 2011-10-20 |
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| journal | Proc Natl Acad Sci U S A |
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| pages | 14479-84 |
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| pubMedIdentifier | 15448205 |
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| title | PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder |
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| volume | 101 |
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| year | 2004 |
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| (literatureReference) | [Reaction:1839039] Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation [Homo sapiens]
[BlackBoxEvent:1839078] Cytosolic FGFR1 fusion proteins bind PIK3R1 [Homo sapiens]
[Reaction:1839080] Activated cytosolic FGFR1 fusions bind PIK3CA [Homo sapiens]
[Reaction:1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:1839102] BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA [Homo sapiens]
[Reaction:5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
[Reaction:5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
[Reaction:5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens]
[Reaction:5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 [Homo sapiens]
[Reaction:5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA [Homo sapiens] |
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