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Details on Person C-ter TLR7 dimer binds TLR7, TLR8 ligands

Class:IdReaction:167983
_displayNameC-ter TLR7 dimer binds TLR7, TLR8 ligands
_doReleaseTRUE
_timestamp2022-03-04 01:54:12
authored[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
compartment[Compartment:74700] endosome membrane
[Compartment:171907] endosome lumen
created[InstanceEdit:168000] Gillespie, ME, 2005-11-10 16:24:09
edited[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input[Complex:1679575] C-ter TLR7 dimer [endosome membrane] [Homo sapiens]
[DefinedSet:9684904] TLR7, TLR8 ligands [endosome lumen] [Human SARS coronavirus]
literatureReference[LiteratureReference:188148] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
[LiteratureReference:188144] Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
[LiteratureReference:188142] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
[LiteratureReference:188159] Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
[LiteratureReference:9684933] Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response
modified[InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22
[InstanceEdit:177474] Gopinathrao, G, 2006-03-30 18:08:55
[InstanceEdit:177514] Gopinathrao, G, 2006-03-31 14:29:10
[InstanceEdit:177804] Gillespie, ME, 2006-04-07 03:21:26
[InstanceEdit:188136] de Bono, B, 2006-09-30 14:24:37
[InstanceEdit:188146] de Bono, B, 2006-09-30 14:30:13
[InstanceEdit:188171] de Bono, B, 2006-09-30 15:05:17
[InstanceEdit:188173] de Bono, B, 2006-09-30 15:07:02
[InstanceEdit:188297] de Bono, B, 2006-10-05 16:37:40
[InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00
[InstanceEdit:188557] Gillespie, ME, 2006-10-17 19:03:28
[InstanceEdit:188744] de Bono, B, 2006-10-27 09:50:22
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:1014280] Shamovsky, V, 2010-11-15
[InstanceEdit:1094905] Shamovsky, V, 2010-11-29
[InstanceEdit:1216506] Shamovsky, V, 2011-02-14
[InstanceEdit:1217494] Shamovsky, V, 2011-02-17
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:1679583] Shamovsky, V, 2011-10-20
[InstanceEdit:9684899] Shamovsky, Veronica, 2020-04-22
[InstanceEdit:9684939] Shamovsky, Veronica, 2020-04-22
[InstanceEdit:9691210] Jassal, Bijay, 2020-06-09
[InstanceEdit:9755440] Shamovsky, Veronica, 2021-10-08
[InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameC-ter TLR7 dimer binds TLR7, TLR8 ligands
output[Complex:188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane] [Homo sapiens]
regulatedBy[NegativeRegulation:9691206] Negative regulation by 'C-ter TLR7 dimer:HCQ [endosome membrane]'
regulationReference[RegulationReference:9691205] Negative regulation by 'C-ter TLR7 dimer:HCQ [endosome membrane]' Novel and Selective TLR7 Antagonists among the Imidazo[1,2-a]pyrazines, Imidazo[1,5-a]quinoxalines, and Pyrazolo[1,5-a]quinoxalines Series
relatedSpecies[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate2010-12-14
reviewed[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361830] R-HSA-167983.6
summation[Summation:188745] Endosomal recognition of viral single stranded (ss) RNA occu...
(hasEvent)[Pathway:168181] Toll Like Receptor 7/8 (TLR7/8) Cascade [Homo sapiens]
[Pathway:9692916] SARS-CoV-1 activates/modulates innate immune responses [Homo sapiens]
(precedingEvent)[Reaction:975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775479] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v79:[modifyText]
[_UpdateTracker:9776426] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v76:[modifyText]
[_UpdateTracker:9776716] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v74:[addRegulator, add_removeInput]
[_UpdateTracker:9777070] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v73:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9788985] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v39:[add_removeInput]
[_UpdateTracker:9789941] Update Tracker - [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands - v36:[add_removeInput]
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