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Details on Person Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer

Class:Id	Reaction:1679098
_displayName	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer
_doRelease	TRUE
_timestamp	2012-09-03 10:29:03
authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:1679095] Shamovsky, V, 2011-10-19
edited	[InstanceEdit:2129343] Shamovsky, V, 2012-02-19
input	[OtherEntity:167913] Unmethylated CpG DNA [endosome membrane] [Complex:1679574] N-ter TLR9 dimer [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:188077] The immunobiology of the TLR9 subfamily [LiteratureReference:1679551] Negative regulation of signaling by a soluble form of toll-like receptor 9
modified	[InstanceEdit:1679583] Shamovsky, V, 2011-10-20 [InstanceEdit:1679591] Shamovsky, V, 2011-10-20 [InstanceEdit:2129010] Shamovsky, V, 2012-02-19 [InstanceEdit:2143409] Shamovsky, V, 2012-02-24 [InstanceEdit:2445243] Shamovsky, V, 2012-08-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer
output	[Complex:1679094] N-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:1678981] TLR9 processing at neutral pH [Homo sapiens] [BlackBoxEvent:1678927] UNC93B1 delivers endosomal full-length TLRs to endolysosome [Homo sapiens]
regulatedBy	[PositiveRegulation:1679582] Positive regulation by 'EEA1:EEA1 [endosome membrane]'
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121211] Gillespie, ME, 2012-02-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2157994] R-HSA-1679098.3
summation	[Summation:1679549] TLR9 traffics to an endosomal vesicle where it is processed ...
(hasEvent)	[Pathway:168138] Toll Like Receptor 9 (TLR9) Cascade [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788398] Update Tracker - [Reaction:1679098] Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer - v42:[addLiteratureReference]
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