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Details on Person Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans

Class:Id	Reaction:1678694
_displayName	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans
_doRelease	TRUE
_timestamp	2025-08-12 22:17:59
authored	[InstanceEdit:1678699] Jassal, B, 2011-10-19
catalystActivity	[CatalystActivity:9954174] protein sequestering activity of HPSE2(1-592) [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1678699] Jassal, B, 2011-10-19
edited	[InstanceEdit:1678699] Jassal, B, 2011-10-19
input	[DefinedSet:2076639] HS/HPIN-PGs [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1678680] HPSE2(1-592) [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06
isChimeric	FALSE
literatureReference	[LiteratureReference:1678690] Mutations in HPSE2 cause urofacial syndrome [LiteratureReference:9774309] Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity [LiteratureReference:1678667] Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member [LiteratureReference:1678621] Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome
modified	[InstanceEdit:1793189] Jassal, B, 2011-10-21 [InstanceEdit:1793232] Jassal, B, 2011-10-21 [InstanceEdit:2022170] Jassal, B, 2011-11-28 [InstanceEdit:2090024] Jassal, B, 2012-02-06 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:9774320] D'Eustachio, Peter, 2022-05-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9954173] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9954177] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9962971] D'Eustachio, Peter, 2025-08-12
name	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans
output	[Complex:9774311] HPSE2:HS/HPIN-PGs [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2024108] Some HSPGs are secreted to the plasma membrane [Homo sapiens] [Reaction:2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) [Homo sapiens] [Reaction:2024100] GLCE epimerises GlcA to IdoA [Homo sapiens] [Reaction:2076371] GLCE epimerises more GlcA to IdoA as sulfate content rises [Homo sapiens] [Reaction:2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate [Homo sapiens] [Reaction:2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate [Homo sapiens] [Reaction:2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9774317] Hill, David P, 2022-05-20 [InstanceEdit:9962972] Hill, David P, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9774306] D'Eustachio, Peter, 2022-05-20
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294861] R-HSA-1678694.4
structureModified	[InstanceEdit:9954173] D'Eustachio, Peter, 2025-06-06
summation	[Summation:1678676] Heparanase 2 (HPSE2) (McKenzie et al. 2000) is a membrane-bo...
(hasEvent)	[Pathway:2024096] HS-GAG degradation [Homo sapiens]
(normalReaction)	[FailedReaction:3656266] Defective HPSE2 does not cleave SO4(2-) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9847017] Update Tracker - [Reaction:1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans - v82:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText, removeCatalystActivity] [_UpdateTracker:9964714] Update Tracker - [Reaction:1678694] Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans - v94:[removeCatalystActivity]
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