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Details on Person Active PLCG1 hydrolyses PIP2

Class:Id	Reaction:167686
_displayName	Active PLCG1 hydrolyses PIP2
_doRelease	TRUE
_timestamp	2025-09-23 15:50:40
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:167676] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-4Y-PLCG1 [plasma membrane]
compartment	[Compartment:947587] cytoplasmic side of plasma membrane [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:167673] Jassal, Bijay, 2005-11-01
crossReference	[DatabaseIdentifier:9947018] RHEA:33180
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
inferredFrom	[Reaction:182061] Active Plcg1 hydrolyses PIP2 [Rattus norvegicus]
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
modified	[InstanceEdit:169684] Jassal, Bijay, 2005-11-30 [InstanceEdit:182105] Jassal, Bijay, 2006-07-06 [InstanceEdit:187655] Jassal, Bijay, 2006-09-21 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188619] Jassal, Bijay, 2006-10-19 [InstanceEdit:190906] de Bono, B, 2007-01-09 16:24:01 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:203530] Jassal, Bijay, 2007-11-14 [InstanceEdit:203531] Jassal, Bijay, 2007-11-14 [InstanceEdit:204297] Jassal, Bijay, 2007-11-28 [InstanceEdit:212707] Jassal, Bijay, 2008-02-13 [InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:660810] D'Eustachio, P, 2010-05-01 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:2029269] Garapati, P V, 2012-01-04 [InstanceEdit:5218914] Garapati, P V, 2013-12-20 [InstanceEdit:5654153] Rothfels, Karen, 2014-12-03 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9966343] Stephan, Ralf, 2025-09-19 [InstanceEdit:9966626] D'Eustachio, Peter, 2025-09-23
name	Active PLCG1 hydrolyses PIP2
output	[SimpleEntity:114520] I(1,4,5)P3 [cytosol] [SimpleEntity:114519] DAG [plasma membrane] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:167684] Active PLCG1 dissociates from TrkA receptor [Homo sapiens] [Reaction:167683] TrkA phosphorylates PLCG1 [Homo sapiens] [Reaction:212713] Active PLC-gamma1 dissociates from EGFR [Homo sapiens] [Reaction:212710] EGFR activates PLC-gamma1 by phosphorylation [Homo sapiens] [Reaction:2029272] Release of PLCG from FCGR [Homo sapiens] [Reaction:2029268] Phosphorylation and activation of PLCG [Homo sapiens] [Reaction:2029271] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:2029273] PI3K binds to p-6Y-SYK [Homo sapiens] [Reaction:4420202] PLCG1 disassociates from VEGFR2 and translocate to PM [Homo sapiens] [Reaction:4420121] SFKs phosphorylate PLCG1 [Homo sapiens] [Reaction:5654157] p-4Y-PLCG1 dissociates from activated FGFR2 [Homo sapiens] [Reaction:5654147] Activated FGFR2 phosphorylates PLCG1 [Homo sapiens] [Reaction:5654148] p-4Y-PLCG1 dissociates from activated FGFR3 [Homo sapiens] [Reaction:5654222] Activated FGFR3 phosphorylates PLCG1 [Homo sapiens] [Reaction:5654169] p-4Y-PLCG1 dissociates from activated FGFR4 [Homo sapiens] [Reaction:5654151] Activated FGFR4 phosphorylates PLCG1 [Homo sapiens] [Reaction:5654165] p-4Y-PLCG1 dissociates from activated FGFR1 [Homo sapiens] [Reaction:5654149] Activated FGFR1 phosphorylates PLCG1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-09-20
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:9966625] D'Eustachio, Peter, 2025-09-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361301] R-HSA-167686.4
structureModified	[InstanceEdit:9966343] Stephan, Ralf, 2025-09-19
summation	[Summation:169699] Inositol 1,4,5-triphosphate (IP3) is a second messenger prod...
(hasEvent)	[Pathway:1489509] DAG and IP3 signaling [Homo sapiens] [Pathway:2029485] Role of phospholipids in phagocytosis [Homo sapiens] [Pathway:5218921] VEGFR2 mediated cell proliferation [Homo sapiens]
(precedingEvent)	[Reaction:139941] Binding of IP3 to IP3 receptor [Homo sapiens] [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:198314] DAG stimulates protein kinase C-delta [Homo sapiens] [Reaction:1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol [Homo sapiens] [Reaction:1855174] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol [Homo sapiens] [Reaction:1855190] I(1,4,5)P3 transports from the cytosol to the nucleus [Homo sapiens] [Reaction:1855222] I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane [Homo sapiens] [Reaction:5218813] DAG and Ca+2 bind to PKC and tether it to membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788981] Update Tracker - [Reaction:167686] Active PLCG1 hydrolyses PIP2 - v39:[modifyText] [_UpdateTracker:9790453] Update Tracker - [Reaction:167686] Active PLCG1 hydrolyses PIP2 - v33:[add_removeOutput] [_UpdateTracker:9971808] Update Tracker - [Reaction:167686] Active PLCG1 hydrolyses PIP2 - v95:[add_removeOutput]
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