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Details on Person Binding of PLCG1 to active TrkA receptor

Class:Id	Reaction:167674
_displayName	Binding of PLCG1 to active TrkA receptor
_doRelease	TRUE
_timestamp	2024-03-18 20:06:14
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:167673] Jassal, Bijay, 2005-11-01
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
inferredFrom	[Reaction:182040] Binding of Plcg1 to active Trk receptor [Rattus norvegicus]
input	[Complex:166540] Activated TrkA receptor complex [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:167682] PLCG1 [plasma membrane] [Homo sapiens]
modified	[InstanceEdit:169684] Jassal, Bijay, 2005-11-30 [InstanceEdit:182105] Jassal, Bijay, 2006-07-06 [InstanceEdit:187655] Jassal, Bijay, 2006-09-21 [InstanceEdit:187903] Jassal, Bijay, 2006-09-29 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188620] Jassal, Bijay, 2006-10-19 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:204298] Jassal, Bijay, 2007-11-28 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
name	Binding of PLCG1 to active TrkA receptor
negativePrecedingEvent	[NegativePrecedingEvent:9865764] Futile Cycle: Phospho-Shc dissociates from the TrkA receptor
output	[Complex:167687] Active TrkA receptor:PLCG1 complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:167684] Active PLCG1 dissociates from TrkA receptor [Homo sapiens] [Reaction:167683] TrkA phosphorylates PLCG1 [Homo sapiens] [Reaction:166544] TrkA receptor autophosphorylates [Homo sapiens] [Reaction:166538] The bound receptor dimerizes [Homo sapiens]
releaseDate	2007-12-11
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360758] R-HSA-167674.3
summation	[Summation:169701] The PLC-gamma 1 docking site in Trk receptor (Y785) is impor...
(hasEvent)	[Pathway:167021] PLC-gamma1 signalling [Homo sapiens]
(precedingEvent)	[Reaction:167683] TrkA phosphorylates PLCG1 [Homo sapiens]
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