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Details on Person PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

Class:Id	Reaction:1676162
_displayName	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
_doRelease	TRUE
_timestamp	2012-05-31 09:41:38
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806174] phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:1806238] PI(3,4)P2 [early endosome membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:1676179] The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase [LiteratureReference:1676120] The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family [LiteratureReference:1675803] The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
output	[SimpleEntity:1806200] PI3P [early endosome membrane] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:1675834] PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane [Homo sapiens] [Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens] [Reaction:1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane [Homo sapiens] [Reaction:1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane [Homo sapiens] [Reaction:1675974] PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294815] R-HSA-1676162.2
summation	[Summation:1675978] At the early endosome membrane, type I (INPP4A) (Norris et a...
(hasEvent)	[Pathway:1660516] Synthesis of PIPs at the early endosome membrane [Homo sapiens]
(precedingEvent)	[Reaction:1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane [Homo sapiens] [Reaction:1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane [Homo sapiens] [Reaction:6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 [Homo sapiens]
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