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Details on Person PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane

Class:Id	Reaction:1676149
_displayName	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
_doRelease	TRUE
_timestamp	2016-11-10 16:23:04
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806248] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:202247] PI(3,4)P2 [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1676004] The lipid phosphatase activity of PTEN is critical for its tumor supressor function [LiteratureReference:1675887] Membrane-binding and activation mechanism of PTEN [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:8948103] Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:8948113] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
output	[SimpleEntity:392417] PI4P [plasma membrane] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens] [Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens] [BlackBoxEvent:1675815] PI4P transports from the Golgi membrane to the plasma membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane [Homo sapiens] [Reaction:1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane [Homo sapiens] [Reaction:1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane [Homo sapiens] [Reaction:1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane [Homo sapiens] [Reaction:1675836] PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294752] R-HSA-1676149.3
summation	[Summation:1675876] At the plasma membrane, phosphatidylinositol-3,4,5-trisphosp...
(hasEvent)	[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782059] Update Tracker - [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - v59:[addLiteratureReference, modifyText]
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