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Details on Person PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

Class:Id	Reaction:1676145
_displayName	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
_doRelease	TRUE
_timestamp	2012-05-31 09:52:55
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806274] 1-phosphatidylinositol-3-phosphate 4-kinase activity of PIP4K2/5K1 [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:1806276] PI3P [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1676156] Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases [LiteratureReference:1675808] Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules [LiteratureReference:1675860] A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate [LiteratureReference:1675873] Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate [LiteratureReference:1675816] Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron [LiteratureReference:480180] Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin [LiteratureReference:1676009] PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2206315] D'Eustachio, P, 2012-04-26 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
output	[SimpleEntity:202247] PI(3,4)P2 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane [Homo sapiens] [Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens] [Reaction:1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane [Homo sapiens] [Reaction:1675836] PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane [Homo sapiens] [Reaction:1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295252] R-HSA-1676145.2
summation	[Summation:1675992] At the plasma membrane, phosphatidylinositol-5-phosphate 4-k...
(hasEvent)	[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane [Homo sapiens] [BlackBoxEvent:1675834] PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane [Homo sapiens] [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane [Homo sapiens] [Reaction:1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane [Homo sapiens]
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