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Details on Person PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

Class:Id	Reaction:1676082
_displayName	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
_doRelease	TRUE
_timestamp	2016-02-29 20:27:24
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806262] 1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1A-C [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:392417] PI4P [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1675808] Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules [LiteratureReference:480180] Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin [LiteratureReference:1676136] A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis [LiteratureReference:2206316] Regulation and cellular roles of phosphoinositide 5-kinases [LiteratureReference:2206317] Phospholipase D signaling: orchestration by PIP2 and small GTPases
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2206318] D'Eustachio, P, 2012-04-26 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:8856766] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
output	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:1675815] PI4P transports from the Golgi membrane to the plasma membrane [Homo sapiens] [Reaction:1676185] PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane [Homo sapiens] [Reaction:1675883] PI is phosphorylated to PI4P by PI4KB at the Golgi membrane [Homo sapiens] [Reaction:1676204] PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane [Homo sapiens] [Reaction:1675824] PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane [Homo sapiens] [Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens] [Reaction:1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Homo sapiens] [Reaction:1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane [Homo sapiens] [Reaction:1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane [Homo sapiens] [Reaction:1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane [Homo sapiens] [Reaction:1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane [Homo sapiens]
releaseDate	2012-06-12
releaseStatus	UPDATED
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:8856765] Porteu, Françoise, 2016-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294852] R-HSA-1676082.3
summation	[Summation:1675833] At the plasma membrane, phosphatidylinositol-4-phosphate 5-k...
(hasEvent)	[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens] [Pathway:6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Homo sapiens]
(precedingEvent)	[Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Homo sapiens] [Reaction:8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783699] Update Tracker - [Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - v56:[modifyText]
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