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Details on Person myristoylated nef [cytosol]
Class:Id EntityWithAccessionedSequence:167605
_displayName myristoylated nef [cytosol]
_timestamp 2016-03-14 11:21:32
compartment [Compartment:70101] cytosol
created [InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
goCellularComponent [Compartment:436407] host cell cytosol
hasModifiedResidue [ModifiedResidue:167595] N-myristoylglycine at 1
modified [InstanceEdit:167706] Gillespie, ME, 2005-11-01 21:01:20 [InstanceEdit:2167930] D'Eustachio, P, 2012-03-23 [InstanceEdit:3076315] Gillespie, ME, 2013-02-06 [InstanceEdit:8864244] Jupe, Steve, 2016-03-14 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name myristoylated nef
referenceEntity [ReferenceGeneProduct:165288] UniProt:P04601 nef [Human immunodeficiency virus 1]
species [Species:164493] Human immunodeficiency virus 1
stableIdentifier [StableIdentifier:371626] R-HIV-167605.20
(hasComponent) [Complex:167554] Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] [Homo sapiens] [Complex:167576] Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] [Homo sapiens] [Complex:167596] CD4:Nef Complex [plasma membrane] [Homo sapiens] [Complex:167629] Nef:CD28 Complex [plasma membrane] [Homo sapiens] [Complex:167631] CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol] [Homo sapiens] [Complex:173664] Viral core surrounded by Matrix layer [cytosol] [Homo sapiens] [Complex:182194] CD8:Nef Complex [plasma membrane] [Homo sapiens] [Complex:182230] Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] [Homo sapiens] [Complex:182254] Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] [Homo sapiens] [Complex:182256] Nef:class I MHC complex [Golgi membrane] [Homo sapiens]
(input) [Reaction:164943] Nef mediated activation of the T-cell receptor [Homo sapiens] [Reaction:167566] Nef mediated disruption of CD4:Lck Complex [Homo sapiens] [Reaction:167630] Formation of Nef CD28 cytoplasmic tail complex [Homo sapiens] [Reaction:182243] Formation of MHC I:Nef Complex [Homo sapiens] [Reaction:200858] Nef Binds and activates the Src-family tyrosine kinase Hck [Homo sapiens] [Reaction:200879] Formation of a Nef:ARF1:CD4 complex [Homo sapiens] [Reaction:200908] Nef Binds and activates the Src-family tyrosine kinase Fyn [Homo sapiens] [Reaction:200952] Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction [Homo sapiens] [Reaction:200954] Nef Binds and activates the Src-family tyrosine kinase Lck [Homo sapiens] [Reaction:3149454] Packaging of HIV virion on the host cell plasma membrane [Homo sapiens]
(output) [Reaction:162914] Myristoylation of Nef [Homo sapiens] [BlackBoxEvent:167601] Degradation of CD4 [Homo sapiens] [Depolymerisation:173642] Disintegration of matrix layer [Homo sapiens] [BlackBoxEvent:182171] Degradation of CD8 [Homo sapiens] [BlackBoxEvent:182263] Degradation of MHC I Complex [Homo sapiens]
(updatedInstance) [_UpdateTracker:9878170] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v44:[modifyName] [_UpdateTracker:9894372] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v57:[modifyName]
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No pathways have been reviewed or authored by myristoylated nef [cytosol] (167605)