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Details on Person PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane

Class:Id	Reaction:1676048
_displayName	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
_doRelease	TRUE
_timestamp	2016-03-04 16:12:00
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806243] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PIK3C(1) [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1675877] The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101 [LiteratureReference:1675852] p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma [LiteratureReference:1676045] Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor [LiteratureReference:1675986] Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [LiteratureReference:1675842] P110delta, a novel phosphoinositide 3-kinase in leukocytes [LiteratureReference:1676076] Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms [LiteratureReference:425636] Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:8863123] D'Eustachio, Peter, 2016-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Homo sapiens] [BlackBoxEvent:1675815] PI4P transports from the Golgi membrane to the plasma membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane [Homo sapiens] [Reaction:1675780] PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane [Homo sapiens] [Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] [Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [BlackBoxEvent:2321904] PTEN mRNA translation negatively regulated by microRNAs [Homo sapiens] [BlackBoxEvent:8944497] PTEN mRNA translation is negatively regulated by microRNAs [Homo sapiens] [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Homo sapiens] [Reaction:1675810] PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane [Homo sapiens] [Reaction:1676203] PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295197] R-HSA-1676048.3
summation	[Summation:1675804] At the plasma membrane, phosphatidylinositol-4,5-bisphosphat...
(hasEvent)	[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens] [Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens]
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No pathways have been reviewed or authored by PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (1676048)