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Details on Person PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane

Class:Id	Reaction:1675982
_displayName	PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane
_doRelease	TRUE
_timestamp	2015-08-04 22:39:29
authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806264] 1-phosphatidylinositol-3-phosphate 5-kinase activity of Pikfyve:VAC14:FIG4 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:1806159] PI3P [Golgi membrane]
isChimeric	TRUE
literatureReference	[LiteratureReference:1675955] PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin [LiteratureReference:1675907] Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases [LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1460276] ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality [LiteratureReference:1676068] Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization
modified	[InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:2248823] D'Eustachio, P, 2012-05-14 [InstanceEdit:4420235] D'Eustachio, P, 2013-08-30 [InstanceEdit:6789869] Matthews, Lisa, 2015-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:1806290] PI(3,5)P2 [Golgi membrane]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus [Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295049] R-NUL-1675982.3
summation	[Summation:1675971] At the Golgi membrane, the PAS complex, consisting of mouse ...
(hasEvent)	[Pathway:1483251] PI Metabolism pathway - Inferred Events
(inferredFrom)	[Reaction:1675921] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane [Homo sapiens]
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