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Details on Person Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex

Class:Id	Reaction:167597
_displayName	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
_doRelease	TRUE
_timestamp	2014-12-12 21:44:21
authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
input	[Complex:167544] CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:182238] Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
modified	[InstanceEdit:167720] Gillespie, ME, 2005-11-01 21:41:58 [InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:170617] Gopinathrao, G, 2006-01-08 02:23:40 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:182300] Gillespie, ME, 2006-07-06 21:32:56 [InstanceEdit:182793] Gillespie, ME, 2006-07-18 19:30:59 [InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36 [InstanceEdit:200907] Gillespie, ME, 2007-07-25 21:01:05 [InstanceEdit:201389] Gillespie, ME, 2007-08-07 14:42:02 [InstanceEdit:201413] Gopinathrao, G, 2007-08-08 14:30:28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:5656435] Gillespie, Marc E, 2014-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
output	[Complex:167554] Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex [Homo sapiens] [Reaction:167566] Nef mediated disruption of CD4:Lck Complex [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358534] R-HSA-167597.2
summation	[Summation:201385] The Nef:CD4:AP-2 complex is internalized
(hasEvent)	[Pathway:167590] Nef Mediated CD4 Down-regulation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:167601] Degradation of CD4 [Homo sapiens] [BlackBoxEvent:182171] Degradation of CD8 [Homo sapiens]
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