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Details on Person PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane
Class:Id Reaction:1675776 _displayName PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane _doRelease TRUE _timestamp 2016-02-29 20:27:25 authored [InstanceEdit:1678579] Williams, MG, 2011-10-18 catalystActivity [CatalystActivity:1806209] 1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol] catalystActivityReference [CatalystActivityReference:9643715] 1-phosphatidylinositol-5-phosphate 4-kinase activity of PIP4K2 dimers [cytosol] Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:1676083] Williams, MG, 2011-10-17 edited [InstanceEdit:1482514] Williams, MG, 2011-08-12 input [SimpleEntity:1806240] PI5P [plasma membrane] [SimpleEntity:113592] ATP [cytosol] isChimeric FALSE literatureReference [LiteratureReference:1675816] Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron [LiteratureReference:1675860] A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate [LiteratureReference:1676156] Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases [LiteratureReference:6808603] Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization [LiteratureReference:6808611] The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site modified [InstanceEdit:1678578] Williams, MG, 2011-10-18 [InstanceEdit:1806251] Williams, MG, 2011-10-24 [InstanceEdit:1967225] Williams, MG, 2011-11-04 [InstanceEdit:2247961] D'Eustachio, P, 2012-05-14 [InstanceEdit:6808612] Orlic-Milacic, Marija, 2015-11-06 [InstanceEdit:8856766] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane output [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:29370] ADP [cytosol] precedingEvent
releaseDate 2012-06-12 releaseStatus UPDATED reviewed [InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:8856765] Porteu, Françoise, 2016-02-08 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2295129] R-HSA-1675776.5 summation [Summation:1675956] At the plasma membrane, phosphatidylinositol-5-phosphate 4-k... (hasEvent) [Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens] [Pathway:6811554] Regulation of PI5P Levels [Homo sapiens] [Pathway:6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Homo sapiens] (precedingEvent) [Reaction:1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Homo sapiens] [Reaction:1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Homo sapiens] [Reaction:1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Homo sapiens] [Reaction:1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Homo sapiens] (updatedInstance) [_UpdateTracker:9784018] Update Tracker - [Reaction:1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - v55:[addLiteratureReference, modifyText]
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