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Details on Person PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

Class:IdReaction:1675773
_displayNamePI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
_doReleaseTRUE
_timestamp2012-05-31 09:46:07
authored[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity[CatalystActivity:1806282] phosphatidylinositol kinase activity of PIP5K1A-C [cytosol]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:1676083] Williams, MG, 2011-10-17
edited[InstanceEdit:1482514] Williams, MG, 2011-08-12
input[SimpleEntity:202247] PI(3,4)P2 [plasma membrane]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1675808] Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
[LiteratureReference:1675873] Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate
[LiteratureReference:1676009] PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse
[LiteratureReference:480180] Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin
[LiteratureReference:1676172] ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma
modified[InstanceEdit:1678578] Williams, MG, 2011-10-18
[InstanceEdit:1806251] Williams, MG, 2011-10-24
[InstanceEdit:1967225] Williams, MG, 2011-11-04
[InstanceEdit:2247961] D'Eustachio, P, 2012-05-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
output[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294989] R-HSA-1675773.2
summation[Summation:1675879] At the plasma membrane, phosphatidylinositol-4-phosphate 5-k...
(hasEvent)[Pathway:1660499] Synthesis of PIPs at the plasma membrane [Homo sapiens]
(precedingEvent)[Reaction:199456] PTEN dephosphorylates PIP3 [Homo sapiens]
[Reaction:1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane [Homo sapiens]
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