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Details on Person Abortive HIV-1 initiation after formation of the first phosphodiester bond

Class:Id	Reaction:167477
_displayName	Abortive HIV-1 initiation after formation of the first phosphodiester bond
_doRelease	TRUE
_timestamp	2021-08-03 19:23:17
authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167476] Matthews, L, 2005-10-18 12:38:13
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
edited	[InstanceEdit:167401] Matthews, L, 2005-10-15 23:27:00
inferredFrom	[Reaction:73946] Abortive initiation after formation of the first phosphodiester bond [Homo sapiens]
input	[Complex:167101] HIV-1 transcription complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:110396] Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.
modified	[InstanceEdit:169296] Vastrik, I, 2005-11-28 11:33:22 [InstanceEdit:170181] Gopinathrao, G, 2005-12-27 21:08:53 [InstanceEdit:170793] Vastrik, I, 2006-01-16 05:24:48 [InstanceEdit:2671730] D'Eustachio, P, 2012-11-23 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:6787529] D'Eustachio, Peter, 2015-07-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9749445] D'Eustachio, Peter, 2021-08-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Abortive HIV-1 initiation after formation of the first phosphodiester bond
output	[GenomeEncodedEntity:167096] HIV-1 template DNA with first transcript dinucleotide, opened to +8 position [nucleoplasm] [Human immunodeficiency virus 1] [Complex:71307] RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] [Homo sapiens] [Complex:109629] TFIIA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:65888] GTF2B [nucleoplasm] [Homo sapiens] [Complex:109626] TFIID [nucleoplasm] [Homo sapiens] [Complex:109633] TFIIE [nucleoplasm] [Homo sapiens] [Complex:109634] TFIIH [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:167134] Newly formed phosphodiester bond stabilized and PPi released [Homo sapiens] [Reaction:167130] Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358295] R-HSA-167477.5
summation	[Summation:178356] At the beginning of this reaction, 1 molecule of 'HIV-1 tran...
(hasEvent)	[Pathway:167161] HIV Transcription Initiation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784139] Update Tracker - [Reaction:167477] Abortive HIV-1 initiation after formation of the first phosphodiester bond - v54:[addLiteratureReference]
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