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Details on Person G-protein alpha subunit is inactivated

Class:Id	Reaction:167415
_displayName	G-protein alpha subunit is inactivated
_doRelease	TRUE
_timestamp	2016-12-01 00:31:40
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:167406] GTPase activity of G-protein alpha (q/11/14/15) [plasma membrane]
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:167422] Jassal, Bijay, 2005-10-18
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input	[SimpleEntity:29420] GDP [cytosol] [Complex:167438] G protein alpha:GTP complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:374843] Mechanism of GTP hydrolysis by G-protein alpha subunits [LiteratureReference:374813] Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
modified	[InstanceEdit:374823] Jassal, B, 2008-08-01 09:28:11 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:629657] Jassal, B, 2010-04-28 [InstanceEdit:843152] Jassal, B, 2010-05-28 [InstanceEdit:849799] Jassal, B, 2010-06-01 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G-protein alpha subunit is inactivated
output	[Complex:111864] G-protein alpha:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
precedingEvent	[Reaction:112271] The receptor:G-protein complex dissociates [Homo sapiens] [Reaction:167429] The receptor:G-protein complex binds GTP [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387579] R-HSA-167415.3
summation	[Summation:167423] Slow intrisinc GTPase activity results in an inactivation of...
(hasEvent)	[Pathway:202040] G-protein activation [Homo sapiens]
(precedingEvent)	[Reaction:167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790416] Update Tracker - [Reaction:167415] G-protein alpha subunit is inactivated - v33:[addInput, add_removeOutput]
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No pathways have been reviewed or authored by G-protein alpha subunit is inactivated (167415)