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Details on Person The high affinity receptor complex binds to G-protein

Class:Id	Reaction:167408
_displayName	The high affinity receptor complex binds to G-protein
_doRelease	TRUE
_timestamp	2008-12-03 09:55:33
authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
catalystActivity	[CatalystActivity:111868] G protein-coupled receptor activity of Opioid:MOR [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:167422] Jassal, Bijay, 2005-10-18
edited	[InstanceEdit:379927] Jassal, Bijay, 2008-11-06
input	[Complex:112039] Opioid:MOR [plasma membrane] [Homo sapiens] [Complex:167418] G protein-GDP complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:374834] Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms [LiteratureReference:374819] Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells [LiteratureReference:374827] Differential activation of G-proteins by mu-opioid receptor agonists [LiteratureReference:375534] Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I
modified	[InstanceEdit:374823] Jassal, B, 2008-08-01 09:28:11 [InstanceEdit:375562] Jassal, B, 2008-09-04 10:45:06 [InstanceEdit:379936] Jassal, Bijay, 2008-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The high affinity receptor complex binds to G-protein
output	[Complex:167403] Opioid:MOR:G protein-GDP complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:112042] Opioid binds MOR [Homo sapiens] [Reaction:167427] Opioid dissociates from MOR [Homo sapiens] [Reaction:167433] G-protein beta-gamma subunits rebind the alpha-GDP subunit [Homo sapiens] [Reaction:167415] G-protein alpha subunit is inactivated [Homo sapiens] [Reaction:6814418] PDCL promotes formation of G-beta:G-gamma heterodimers [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387561] R-HSA-167408.2
summation	[Summation:167430] The high affinity complex beta-endorphin:mu opioid receptor ...
(hasEvent)	[Pathway:202040] G-protein activation [Homo sapiens]
(precedingEvent)	[Reaction:167419] The receptor:G-protein complex releases GDP [Homo sapiens]
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No pathways have been reviewed or authored by The high affinity receptor complex binds to G-protein (167408)